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Interleukin-8

Known as: Granulocyte Chemotactic Peptide-Interleukin-8, Chemotactic Factor, Macrophage Derived, Monocyte-Derived Neutrophil Chemotactic Factor 
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types… 
National Institutes of Health

Related topics

Related topics

20 relations
CXCL8 geneChemotactic FactorsIL8 wt AlleleIn Blood

Narrower (2)

CXCL8 protein, humanCXCL8(3-73)K11R,G31P, bovine

Broader (2)

Interleukinscytokine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer.
The proinflammatory chemokine interleukin-8 (IL-8) is undetectable in androgen-responsive prostate cancer cells (e.g., LNCaP and… 
Highly Cited
2004
Highly Cited
2004
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… 
Review
2001
Review
2001
Interleukin-8 and human cancer biology.
Review
2000
Review
2000
Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation.
Since the discovery 13 years ago of interleukin (IL)-8 as a potent neutrophil chemotactic factor, accumulating evidence has… 
Highly Cited
1999
Highly Cited
1999
Distinct patterns and kinetics of chemokine production regulate dendritic cell function
Dendritic cells (DC) have been showed to both produce and respond to chemokines. To understand how this may impact on DC function… 
Highly Cited
1997
Highly Cited
1997
Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.
Expression of interleukin-8 (IL-8) by human melanoma cells correlates with their metastatic potential. Moreover, UV-B irradiation… 
Highly Cited
1994
Highly Cited
1994
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities… 
Highly Cited
1993
Highly Cited
1993
IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.
Normal melanocytes require a number of exogenous growth factors in contrast to most metastatic malignant melanomas. This… 
Highly Cited
1986
Highly Cited
1986
Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils.
Platelet-activating factor (PAF-acether), an inflammatory mediator with a wide range of biological activities including… 
Highly Cited
1982
Highly Cited
1982
Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.
Intravascular activation of the complement system with cobra venom factor results in acute lung injury, which has been… 
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