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Interleukin-15 Receptor alpha Subunit

Known as: IL-15R alpha, Interleukin 15 Receptor alpha, Interleukin-15 Receptor alpha Subunit [Chemical/Ingredient] 
A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA… Expand
National Institutes of Health

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IL15RA geneIn Bloodagonistsantagonists & inhibitors
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Interleukin-15 Receptor Subunit Alpha, human

Papers overview

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2010
2010
Serum and muscle interleukin-15 levels decrease in aging mice: Correlation with declines in soluble interleukin-15 receptor alpha expression
Interleukin-15 (IL-15) is a skeletal muscle-derived cytokine with favorable effects on muscle mass and body composition… Expand
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Highly Cited
2009
Highly Cited
2009
Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets.
Interleukin-15 receptor alpha (IL-15R alpha) is a pleiotropically expressed molecule that chaperones and trans-presents IL-15 to… Expand
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2009
2009
Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.
Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its… Expand
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2007
2007
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
MHC class II-expressing double-positive thymocytes induce progression of CD4(+) T cell development as efficiently as cortical… Expand
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Highly Cited
2006
Highly Cited
2006
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.
Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural killer (NK), NK-T cells, and memory… Expand
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Review
2005
Review
2005
The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?
Interleukin-15 receptor alpha (IL-15R alpha) is a high affinity IL-15 binding protein that is crucial for mediating IL-15… Expand
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Highly Cited
2004
Highly Cited
2004
Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist.
IL-15 and IL-2 are two structurally and functionally related cytokines whose high affinity receptors share the IL-2R beta-chain… Expand
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Highly Cited
2003
Highly Cited
2003
IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.
The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of… Expand
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1999
1999
Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression.
We report the existence of eight different interleukin-15 receptor alpha-chain (IL-15Ralpha) transcripts resulting from exon… Expand
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Highly Cited
1995
Highly Cited
1995
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
Interleukins-2 and -15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological effects. Their receptors share two… Expand
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