FAQ

Interleukin-15 Receptor alpha Subunit

Known as: IL-15R alpha, Interleukin 15 Receptor alpha, Interleukin-15 Receptor alpha Subunit [Chemical/Ingredient] 
A low affinity interleukin-15 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
0246819952017

Related topics

Related topics

9 relations
IL15RA geneIn Bloodadministration & dosageagonists
(More)

Narrower (1)

Interleukin-15 Receptor Subunit Alpha, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Interleukin-15 Receptor alpha Subunit
physiological aspects
agonists
IL15RA gene
In Blood
Interleukin-15 Receptor Subunit Alpha, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing… (More)
Is this relevant?
2008
2008
How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha.
While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about… (More)
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action.
In the induction of an immune response, IL-15Ralpha on APCs transpresents IL-15 to NK and CD8(+)/CD44(high) T cells that express… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.
Interleukin-15 (IL-15) is crucial for the generation of multiple lymphocyte subsets (natural killer (NK), NK-T cells, and memory… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells.
NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells.
IL-15 is critical for generation of multiple lymphoid subsets. Recent data have demonstrated a unique aspect of responses to IL… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.
IL-15 and the IL-15 receptor (IL-15R)alpha chain are essential for normal development of naive CD8 T cells, intestinal… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
IL-15 promotes the survival of naive and memory phenotype CD8+ T cells.
IL-15 stimulates the proliferation of memory phenotype CD44(high)CD8(+) T cells and is thought to play a key role in regulating… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
Interleukins-2 and -15 (IL-2 and IL-15) are cytokines with overlapping but distinct biological effects. Their receptors share two… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.
Interleukin-15 (IL-15) is a novel cytokine of the four-helix bundle family which shares many biological activities with IL-2… (More)
Is this relevant?