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IL-15/IL-15 receptor biology: a guided tour through an expanding universe.
TLDR
Recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells are reviewed in the context of their potential clinical and therapeutic relevance. Expand
TLR signaling in mast cells: common and unique features
TLDR
Given the location of mast cells at sites exposed to the environment, the response of these cells to TLR ligands must be carefully regulated, and the known mechanisms behind this regulation are reviewed. Expand
Interleukin-21 inhibits dendritic cell activation and maturation.
TLDR
Results identify a dichotomous action of these structurally related cytokines on DCs, establishing IL-21 as inhibitory cytokine on DC activation and IL-15 as potent stimulator of DC function, making both cytokines interesting targets for therapeutic manipulation of DC-induced immune reactions. Expand
Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming1
TLDR
The finding that T cells represent direct targets of IFN-αβ-mediated stimulation reveals an additional mechanism by which the innate response to infection promotes adaptive immunity. Expand
Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15.
TLDR
It is demonstrated that biologically active IL-15 is indeed detectable in a constitutively expressed, membrane-bound form on normal human monocytes, as well as on monocytic cell lines, but not on human T or B cells (MT4, M9, C5966, JURKAT, DAUDI, RAJI, and Epstein-Barr virus-immortalized B-cell clones). Expand
Dendritic cell‐derived IL‐15 controls the induction of CD8 T cell immune responses
TLDR
The data suggest that an autocrine IL‐15/IL‐15Rα signaling loop in DC is essential for inducing CD8+‐dependent Th1 immune responses in mice and targeted manipulation of this loop promises to be an effective, novel strategy for therapeuticmodulation of clinically relevant DTH reactions. Expand
TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment.
TLDR
It is demonstrated that poly(I:C) injection in vivo potently stimulates peritoneal mast cells to up-regulate a number of different costimulatory molecules and mast cells stimulated through engagement of TLR3 are potent regulators of CD8+ T-cell activities in vitro and in vivo. Expand
Extracellular ATP Induces Cytokine Expression and Apoptosis through P2X7 Receptor in Murine Mast Cells
TLDR
The nucleotide selectivity and pharmacological profile data support the role for P2X7 receptor as the mediator of the ATP-induced responses in mast cells and facilitate the development of new strategies to modulate mast cell activities. Expand
Inhibition of Keratinocyte Apoptosis by IL-15: A New Parameter in the Pathogenesis of Psoriasis?1
TLDR
Investigating primary human foreskin KC and HaCaT cells, it is shown that human KC can employ IL-15 for juxtacrine signaling, and antagonizing the inhibitory effects ofIL-15 on KC apoptosis deserves exploration as a novel therapeutic strategy in psoriasis management. Expand
Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum
TLDR
It is shown that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl involves the activity of disintegrin-like metalloproteinase 10 (ADAM10), and ADAM10-mediated proteolysis constitutes a major mechanism for sAxl generation in mice. Expand
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