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Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
TLDR
It is demonstrated that expression of GARP on activated Tregs correlates with their suppressive capacity, and GARP expression correlates with FOXP3-expressing T cells in human immunodeficiency virus (HIV) −infected subjects. Expand
Plasmodium Circumsporozoite Protein Promotes the Development of the Liver Stages of the Parasite
TLDR
It is shown that Plasmodium uses a PEXEL/VTS motif to introduce the circumsporozoite (CS) protein into the hepatocyte cytoplasm and a nuclear localization signal (NLS) to enter its nucleus and enhances parasite growth of the liver stages in vitro and in vivo. Expand
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
TLDR
Interleukin-2 receptor subunits Jak1 and Jak3 were found to be selectively associated with the "serine-rich" region of IL-2R beta and the carboxyl-terminal region ofIL-1R gamma, respectively, which may be a key event inIL-2 signaling. Expand
Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression
TLDR
Findings reveal a novel cell surface molecule-mediated regulatory mechanism, called GARP, which within T cells is specifically expressed in Tregs activated through the T cell receptor (TCR), with implications for modulating aberrant immune responses. Expand
Regulation of the Expression of GARP/Latent TGF-β1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation
TLDR
GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of conventional T cells in vitro. Expand
Efficient isolation of specific genomic regions and identification of associated proteins by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR.
  • T. Fujita, H. Fujii
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 13 September 2013
TLDR
It is shown that enChIP using the CRISPR system efficiently isolates specific genomic regions and would be a convenient and useful tool for dissecting chromatin structure of genomic regions of interest. Expand
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
TLDR
It is demonstrated that the human Stat5 is activated by IL-2 and that Jak3 is required for the efficient activation, and the cytoplasmic region of theIL-2R beta c chain required for activation of Stat 5 is mapped within the carboxyl-terminal 147 amino acids. Expand
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.
TLDR
It is demonstrated that Pyk2, which belongs to another PTK family, is critical for the Jak-mediated MAPK and Stat1 activation by IFn-gamma, but not IFN-alpha, which is severely impaired by PKM overexpression. Expand
Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency.
TLDR
It is demonstrated that defects in IL-2R/1L-15Rbeta expression can lead to a unique NK-deficient SCID immunophenotype. Expand
Protein tyrosine kinase Pyk2 mediates the Jak‐dependent activation of MAPK and Stat1 in IFN‐γ, but not IFN‐α, signaling
TLDR
It is demonstrated that Pyk2, which belongs to another PTK family, is critical for the Jak‐mediated MAPK and Stat1 activation by IFN‐γ, but not IFN-α, and the antiviral action of IFn‐γ‐ but notIFN‐α, is severely impaired by PKM overexpression. Expand
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