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Interferon-Induced Helicase, IFIH1

Known as: Interferon-Induced Helicase C Domain-Containing Protein 1, Melanoma Differentiation-Associated Protein 5, CADM-140 Autoantigen 
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such… 
National Institutes of Health

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IFIH1 geneIn BloodProcess of secretionantagonists & inhibitors

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IFIH1 protein, human

Papers overview

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Highly Cited
2014
Highly Cited
2014
HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection
Hepatitis C virus (HCV) exposure leads to persistent life‐long infections characterized by chronic inflammation often developing… 
2014
2014
Functional characterization of DnaB helicase and its modulation by single‐stranded DNA binding protein in Mycobacterium tuberculosis
DnaB is important in the initiation and extension stages of DNA replication. Although DnaB has been studied in many bacterial… 
2009
2009
Three-Dimensional Structure of N-Terminal Domain of DnaB Helicase and Helicase-Primase Interactions in Helicobacter pylori
Replication initiation is a crucial step in genome duplication and homohexameric DnaB helicase plays a central role in the… 
2005
2005
Helicobacter pylori DnaB helicase can bypass Escherichia coli DnaC function in vivo.
In Escherichia coli, DnaC is essential for loading DnaB helicase at oriC (the origin of chromosomal DNA replication). The… 
2000
2000
Kinetic mechanism of nucleotide cofactor binding to Escherichia coli replicative helicase DnaB protein. stopped-flow kinetic studies using fluorescent, ribose-, and base-modified nucleotide analogues…
The kinetic mechanism of binding nucleotide cofactors to the Escherichia coli primary replicative helicase DnaB protein has been… 
1997
1997
Functional Properties of Replication Fork Assemblies Established by the Bacteriophage λ O and P Replication Proteins*
We have used a set of bacteriophage λ andEscherichia coli replication proteins to establish rolling circle DNA replication in… 
1995
1995
The Bacillus subtilis dnaC gene encodes a protein homologous to the DnaB helicase of Escherichia coli.
Within the region of the Bacillus subtilis chromosome assigned to us in the genome sequencing project, we found a gene, the… 
1995
1995
The speed of the Escherichia coli fork in vivo depends on the DnaB:DnaC ratio
The DnaC protein is required for loading the DnaB helicase at oriC. Thus DnaC promotes the formation of the pre‐replication… 
1993
1993
Strand switching of a replicative DNA helicase promoted by the E. coli primosome
Highly Cited
1990
Highly Cited
1990
Host virus interactions in the initiation of bacteriophage lambda DNA replication. Recruitment of Escherichia coli DnaB helicase by lambda P replication protein.
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