Interferon-Induced Helicase, IFIH1

Known as: Interferon-Induced Helicase C Domain-Containing Protein 1, Melanoma Differentiation-Associated Protein 5, CADM-140 Autoantigen 
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such… (More)
National Institutes of Health

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IFIH1 geneIn BloodProcess of secretionantagonists & inhibitors
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IFIH1 protein, human

Papers overview

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Highly Cited
2013
Highly Cited
2013
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.
Retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are paralogous receptors for… (More)
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Highly Cited
2010
Highly Cited
2010
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.
MCM2-7 proteins provide essential helicase functions in eukaryotes at chromosomal DNA replication forks. During the G1 phase of… (More)
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Highly Cited
2009
Highly Cited
2009
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
Genome-wide association studies (GWASs) are regularly used to map genomic regions contributing to common human diseases, but they… (More)
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Highly Cited
2009
Highly Cited
2009
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial…
OBJECTIVE To identify the autoantigen recognized by the autoantibody that is associated with clinically amyopathic… (More)
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Highly Cited
2009
Highly Cited
2009
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.
The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found… (More)
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Highly Cited
2008
Highly Cited
2008
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.
Fanconi anemia (FA) is a heritable human cancer-susceptibility disorder, delineating a genetically heterogenous pathway for the… (More)
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Highly Cited
2007
Highly Cited
2007
Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.
The MCM2-7 helicase complex is loaded on DNA replication origins during the G1 phase of the cell cycle to license the origins for… (More)
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Highly Cited
2007
Highly Cited
2007
Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase.
The complex between the DnaB helicase and the DnaG primase unwinds duplex DNA at the eubacterial replication fork and synthesizes… (More)
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Highly Cited
2005
Highly Cited
2005
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase.
In eukaryotes, numerous lines of evidence have coalesced into a convincing case that the MCM2-7 complex - a heterohexameric… (More)
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Highly Cited
1997
Highly Cited
1997
DNA double-strand breaks caused by replication arrest.
We report here that DNA double-strand breaks (DSBs) form in Escherichia coli upon arrest of replication forks due to a defect in… (More)
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