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Infant Acute Lymphoblastic Leukemia

An acute lymphoblastic leukemia that occurs in infancy.
National Institutes of Health

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13 relations
Atypical lymphocyteBone MarrowHematopoietic and Lymphoid CellHematopoietic and Lymphoid Tissue

Papers overview

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Highly Cited
2013
Highly Cited
2013
Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants
Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of… 
Highly Cited
2010
Highly Cited
2010
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.
Cooperating leukemogenic events in MLL-rearranged (MLL-r) infant acute lymphoblastic leukemia (ALL) are largely unknown. We… 
Highly Cited
2003
Highly Cited
2003
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene… 
Highly Cited
2002
Highly Cited
2002
Infant acute lymphoblastic leukemia – combined cytogenetic, immunophenotypical and molecular analysis of 77 cases
We used karyotyping, fluorescence in situ hybridization (FISH), Southern blotting, and RT-PCR in order to analyze prospectively… 
Highly Cited
1999
Highly Cited
1999
Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia.
To define prognostic factors in infant acute lymphoblastic leukemia (ALL), the outcome of 106 infants (age </=12 months) during 3… 
Highly Cited
1999
Highly Cited
1999
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice… 
Highly Cited
1999
Highly Cited
1999
Cytogenetic studies of infant acute lymphoblastic leukemia: poor prognosis of infants with t(4;11) – a report of the Children’s Cancer Group
Infants less than 1 year of age at diagnosis of acute lymphoblastic leukemia (ALL) have a poor prognosis, which has been… 
Highly Cited
1997
Highly Cited
1997
Therapeutic trial for infant acute lymphoblastic leukemia: the Pediatric Oncology Group experience (POG 8493).
PURPOSE Despite improved event-free survival of older children with acute lymphocytic leukemia (ALL), infants <1 year of age… 
Highly Cited
1994
Highly Cited
1994
Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Chromosome band 11q23, the location of the HRX gene, is a site of recurrent translocations in human malignancies. Infants with… 
Highly Cited
1993
Highly Cited
1993
Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome.
Acute lymphoblastic leukemia (ALL) in infants generally shows distinctive biologic features and has a poor prognosis. Cytogenetic… 
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