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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
It is suggested that direct disruption of pathways controlling B-cell development and differentiation contributes to B-progenitor ALL pathogenesis and the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer.
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
The gene-expression signature of the group of patients with a poor outcome revealed increased expression of hematopoietic stem-cell genes and reduced expression of B-cell-lineage genes, and it was similar to the signature of BCR-ABL1-positive ALL, another high-risk subtype of ALL with a high frequency of IKZF1 deletion.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
- K. Roberts, Yongjin Li, C. Mullighan
- Biology, MedicineNew England Journal of Medicine
- 11 September 2014
Ph-like ALL was found to be characterized by a range of genomic alterations that activate a limited number of signaling pathways, all of which may be amenable to inhibition with approved tyrosine kinase inhibitors.
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Genetic lesions resulting in the loss of Ikaros function are an important event in the development of BCR–ABL1 ALL, according to genome-wide analysis of diagnostic leukaemia samples.
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.
Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review.
Standardized guidelines are needed to aid in the stratification of patients according to risk and to establish prophylaxis and treatment recommendations for patients at risk or with established TLS.
Biology, risk stratification, and therapy of pediatric acute leukemias: an update.
- C. Pui, W. Carroll, S. Meshinchi, R. Arceci
- Medicine, BiologyJournal of Clinical Oncology
- 10 February 2011
The application of new high-throughput sequencing techniques to define the complete DNA sequence of leukemia and host normal cells and the development of new agents targeted to leukemogenic pathways promise to further improve outcome in the coming decade.