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Immunoglobulin Heavy Chain Complementarity Determining Region 3

Known as: Antibody Heavy Chain Complementarity Determining Region 3, CDR-H3, CDR3 
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and… 
National Institutes of Health

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Related topics

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Immunoglobulin Variable Region

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its… 
Highly Cited
2003
Highly Cited
2003
Estradiol enhances primary antigen‐specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor α expression in hematopoietic cells
It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T… 
Highly Cited
1997
Highly Cited
1997
Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells
A subset of human CD4−CD8− T cells that expresses an invariant Vα24-JαQ T cell receptor (TCR)-α chain, paired predominantly with… 
Highly Cited
1996
Highly Cited
1996
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
Leukaemic cells from most cases of B‐chronic lymphocytic leukaemia die rapidly by apoptosis in vitro unless they are cultured in… 
Highly Cited
1995
Highly Cited
1995
Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment
The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL) response is important in the clearance of… 
Highly Cited
1993
Highly Cited
1993
Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus
Only a fraction (12%) of 268 "autoreactive" T cell clones derived from lupus-prone mice can selectively induce the production of… 
Highly Cited
1993
Highly Cited
1993
Antigen-driven B cell differentiation in vivo
The secretion of specific antibodies and the development of somatically mutated memory B cells in germinal centers are… 
Highly Cited
1993
Highly Cited
1993
Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.
Structural models for the TCR alpha/beta predict that the CDR1, CDR2, and CDR3 loops of both the alpha- and beta-chains… 
Highly Cited
1992
Highly Cited
1992
By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro.
Highly Cited
1991
Highly Cited
1991
Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes
We have examined at the molecular level the CDR3 and adjacent regions in peripheral blood B lymphocytes of normal individuals. A… 
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