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Immunoglobulin Heavy Chain Complementarity Determining Region 3

Known as: Antibody Heavy Chain Complementarity Determining Region 3, CDR-H3, CDR3 
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one… 
Highly Cited
2009
Highly Cited
2009
The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient… 
Highly Cited
2005
Highly Cited
2005
The molecular basis of gd T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural… 
Highly Cited
2004
Highly Cited
2004
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27… 
Highly Cited
2000
Highly Cited
2000
By analyzing the human antibody repertoire in terms of structure, amino acid sequence diversity and germline usage, we found that… 
Review
1998
Review
1998
While still incomplete, the first data concerning the biochemistry of T cell receptor-ligand interactions in cell-free systems… 
Highly Cited
1998
Highly Cited
1998
To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain… 
Highly Cited
1998
Highly Cited
1998
The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation… 
Highly Cited
1993
Highly Cited
1993
A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell…