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Immunoglobulin Heavy Chain Complementarity Determining Region 3

Known as: Antibody Heavy Chain Complementarity Determining Region 3, CDR-H3, CDR3 
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and… 
National Institutes of Health

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Related topics

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Immunoglobulin Variable Region

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Heterosubtypic Immunity to Influenza A Virus Infection Requires a Properly Diversified Antibody Repertoire
ABSTRACT Heterosubtypic immunity (HSI) is defined as cross-protection to infection with an influenza A virus serotype other than… 
Highly Cited
2003
Highly Cited
2003
Antibody Repertoire Development in Fetal and Neonatal Piglets. VI. B Cell Lymphogenesis Occurs at Multiple Sites with Differences in the Frequency of In-frame Rearrangements1
B cell lymphogenesis in mammals occurs in various tissues during development but it is generally accepted that it operates by the… 
Highly Cited
2000
Highly Cited
2000
Frequent Contribution of T Cell Clonotypes with Public TCR Features to the Chronic Response Against a Dominant EBV-Derived Epitope: Application to Direct Detection of Their Molecular Imprint on the…
In an attempt to provide a global picture of the TCR repertoire diversity of a chronic T cell response against a common Ag, we… 
Highly Cited
1996
Highly Cited
1996
Affinity maturation of recombinant antibodies using E. coli mutator cells.
Highly Cited
1996
Highly Cited
1996
Mitogens, superantigens, and nominal antigens elicit distinctive patterns of TCRB CDR3 diversity.
Highly Cited
1994
Highly Cited
1994
Evidence that the clonogenic cell in multiple myeloma originates from a pre‐switched but somatically mutated B cell
Summary. There is still much controversy about the precursor cell type in multiple myeloma (MM). Some authors claim that it is a… 
Review
1994
Review
1994
Molecular analysis of anti‐DNA antibodies
There are two major reasons for interest in antibodies to DNA: autoantibodies to DNA are characteristic of the autoimmune disease… 
Highly Cited
1993
Highly Cited
1993
Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity.
We have used multiple-amino acid replacement mutagenesis to examine the roles of the TCR homologues of Ig complementarity… 
Highly Cited
1992
Highly Cited
1992
Three-dimensional structure of an Fv from a human IgM immunoglobulin.
Highly Cited
1986
Highly Cited
1986
Sequences and repertoire of human T cell receptor alpha chain variable region genes in mature T lymphocytes
24 human T cell receptor alpha chain messages have been examined by cDNA sequence analysis and Southern blot. The data indicate… 
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