Immunoglobulin Heavy Chain Complementarity Determining Region 3

Known as: Antibody Heavy Chain Complementarity Determining Region 3, CDR-H3, CDR3 
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Antibodies' protective, pathological, and therapeutic properties result from their considerable diversity. This diversity is… (More)
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2010
2010
Pemphigus is a life-threatening autoimmune disease in which antibodies specific for desmogleins (Dsgs) cause loss of keratinocyte… (More)
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Highly Cited
2009
Highly Cited
2009
The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient… (More)
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Highly Cited
2005
Highly Cited
2005
The molecular basis of gd T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural… (More)
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Highly Cited
2000
Highly Cited
2000
All rearranging antigen receptor genes have one or two highly diverse complementarity determining regions (CDRs) among the six… (More)
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2000
2000
To determine the contribution of the somatic point mutations and that of the complementarity-determining region (CDR)3 Arg to DNA… (More)
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Highly Cited
1995
Highly Cited
1995
The VH gene repertoire of human peripheral B cells was analyzed using PCR analysis of individual blood B cells. Because genomic… (More)
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Highly Cited
1994
Highly Cited
1994
We cloned 17 different PCR fragments encoding VH genes of camel (Camelus dromedarius). These clones were derived from the camel… (More)
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Highly Cited
1991
Highly Cited
1991
We have examined at the molecular level the CDR3 and adjacent regions in peripheral blood B lymphocytes of normal individuals. A… (More)
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Highly Cited
1991
Highly Cited
1991
By examining a large database of amino acid sequences of antibodies of various specificities, we have found that many antibodies… (More)
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