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Immunoglobulin Heavy Chain Complementarity Determining Region 3

Known as: Antibody Heavy Chain Complementarity Determining Region 3, CDR-H3, CDR3 
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient… Expand
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Highly Cited
2005
Highly Cited
2005
The molecular basis of gd T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural… Expand
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Highly Cited
2004
Highly Cited
2004
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27… Expand
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Highly Cited
2000
Highly Cited
2000
By analyzing the human antibody repertoire in terms of structure, amino acid sequence diversity and germline usage, we found that… Expand
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Highly Cited
2000
Highly Cited
2000
All rearranging antigen receptor genes have one or two highly diverse complementarity determining regions (CDRs) among the six… Expand
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Highly Cited
1998
Highly Cited
1998
To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain… Expand
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Review
1998
Review
1998
While still incomplete, the first data concerning the biochemistry of T cell receptor-ligand interactions in cell-free systems… Expand
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Highly Cited
1998
Highly Cited
1998
The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation… Expand
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Highly Cited
1993
Highly Cited
1993
A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell… Expand
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Highly Cited
1993
Highly Cited
1993
Only a fraction (12%) of 268 "autoreactive" T cell clones derived from lupus-prone mice can selectively induce the production of… Expand
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