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Immunoglobulin Heavy Chain Complementarity Determining Region 3
Known as:
Antibody Heavy Chain Complementarity Determining Region 3
, CDR-H3
, CDR3
An amino acid sequence within the hypervariable region of an immunoglobulin heavy chain that includes parts of the variable (V), diversity (D), and…
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National Institutes of Health
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Related topics
Related topics
1 relation
Immunoglobulin Variable Region
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Identifying specificity groups in the T cell receptor repertoire
J. Glanville
,
Huang Huang
,
+14 authors
Mark M. Davis
Nature
2017
Corpus ID: 4443165
T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one…
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Highly Cited
2009
Highly Cited
2009
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.
H. Robins
,
P. Campregher
,
+6 authors
C. Carlson
Blood
2009
Corpus ID: 206880573
The adaptive immune system uses several strategies to generate a repertoire of T- and B-cell antigen receptors with sufficient…
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Highly Cited
2005
Highly Cited
2005
Do 15-Month-Old Infants Understand False Beliefs ?
Sunny Shin
,
R. El-Diwany
,
+4 authors
Y. Chien
2005
Corpus ID: 20953856
The molecular basis of gd T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural…
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Highly Cited
2004
Highly Cited
2004
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire.
S. Weller
,
M. Braun
,
+13 authors
J. Weill
Blood
2004
Corpus ID: 9160214
The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27…
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Highly Cited
2000
Highly Cited
2000
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.
A. Knappik
,
L. Ge
,
+7 authors
B. Virnekäs
Journal of Molecular Biology
2000
Corpus ID: 15340484
By analyzing the human antibody repertoire in terms of structure, amino acid sequence diversity and germline usage, we found that…
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Highly Cited
2000
Highly Cited
2000
Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities.
John Xu
,
M. Davis
Immunity
2000
Corpus ID: 43126043
Review
1998
Review
1998
Ligand recognition by alpha beta T cell receptors.
Mark M. Davis
,
J. Boniface
,
+4 authors
Y. Chien
Annual Review of Immunology
1998
Corpus ID: 40358545
While still incomplete, the first data concerning the biochemistry of T cell receptor-ligand interactions in cell-free systems…
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Highly Cited
1998
Highly Cited
1998
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
F. Fais
,
F. Ghiotto
,
+12 authors
N. Chiorazzi
Journal of Clinical Investigation
1998
Corpus ID: 22707541
To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain…
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Highly Cited
1998
Highly Cited
1998
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
K. Garcia
,
M. Degano
,
+4 authors
I. Wilson
Science
1998
Corpus ID: 101776
The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation…
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Highly Cited
1993
Highly Cited
1993
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.
C. Pannetier
,
M. Cochet
,
S. Darche
,
A. Casrouge
,
M. Zoller
,
P. Kourilsky
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 23124997
A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell…
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