CDR3 loop flexibility contributes to the degeneracy of TCR recognition

  title={CDR3 loop flexibility contributes to the degeneracy of TCR recognition},
  author={Jean-Baptiste Reiser and Claudine Darnault and Claude Gr{\'e}goire and Thomas Mosser and Gilbert Mazza and Alice Kearney and P. Anton van der Merwe and Juan C Fontecilla-Camps and Dominique Housset and Bernard Malissen},
  journal={Nature Immunology},
T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2Kb major histocompatibility complex molecule at a 2.7 Å resolution, and compared it with the BM3.3 TCR bound to the H-2Kb molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these… CONTINUE READING


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