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Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for… Expand IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the airway mucosa would reduce airway… Expand Total serum immunoglobulin (Ig)E levels are genetically regulated, but the mechanism of inheritance is not well understood… Expand INTERLEUKIN-4(IL-4) is a pleiotropic lymphokine which plays an important role in the immune system1. IL-4 activates two distinct… Expand Interleukin-4 (IL-4) stimulation of cells leads to the activation of multiple signaling pathways, one of which involves Stat6. We… Expand SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines… Expand Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1… Expand CD40 is an integral membrane protein found on the surface of B lymphocytes, dendritic cells, follicular dendritic cells… Expand We purified poly(A)+ mRNA from the spleen and lymph nodes at designated times after infection with Leishmania major in… Expand Gamma interferon (IFN-gamma) and B cell stimulatory factor-1 (BSF-1), also known as interleukin-4, are T cell-derived lymphokines… Expand