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Molecular Phylogenies of Blastocystis Isolates from Different Hosts: Implications for Genetic Diversity, Identification of Species, and Zoonosis
TLDR
The results strongly suggest the existence of numerous zoonotic isolates with frequent animal- to-human and human-to-animal transmissions and of a large potential reservoir in animals for infections in humans. Expand
Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
TLDR
Comparing the immune responses of patients who died from Ebola virus disease with those who survived during two large outbreaks in 1996 in Gabon suggests events very early in Ebola virus infection determine the control of viral replication and recovery or catastrophic illness and death. Expand
Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids.
TLDR
iNKT cell activation in response to TLR9 stimulation required combined synthesis of type I interferon and de novo production of charged beta-linked glycosphingolipid(s) by DCs, which underline the role of TLR 9 in iN KT cell activation and might have relevance to infectious diseases and cancer. Expand
Inflammatory responses in Ebola virus‐infected patients
TLDR
Recovery from Ebo‐Z infection is associated with early and well‐regulated inflammatory responses, which may be crucial in controlling viral replication and inducing specific immunity. Expand
Inflammatory alterations in mesenteric adipose tissue in Crohn's disease.
TLDR
Results suggest that confined increased PPARgamma mesenteric concentrations could lead to the mesentero-abdominal fat hypertrophy, which could actively participate through the synthesis of TNF-alpha in the inflammatory response. Expand
Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon γ)
TLDR
The results suggest that the release of type 1 (IFN-γ and IL-2) versus type 2 cytokines by eosinophils is not only differential but also dependent on cross-regulatory signals. Expand
Molecular epidemiology of human Blastocystis isolates in France
TLDR
This study determined the frequency of different Blastocystis subtypes in patients in France and hypothesized on the mode of transmission and tested a possible relationship between the subtype and symptomatic status. Expand
High-affinity IgE receptor on eosinophils is involved in defence against parasites
TLDR
Results indicate that FcεRI may play a major part in immune defence against parasites and participates in eosinophil-mediated cytotoxicity against S. mansoni. Expand
Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion
TLDR
It is demonstrated that eos inophils, under physiological stimulation, can release significant amounts of IL-5, which may contribute to local eosinophil recruitment and activation. Expand
Human asymptomatic Ebola infection and strong inflammatory response
TLDR
The asymptomatic, replicative Ebola infection can and does occur in human beings, and the lack of genetic differences between symptomatic and asymPTomatic individuals suggest that asymptonomatic Ebola infection did not result from viral mutations. Expand
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