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Immunoglobulin Class Switch Recombination

Known as: Immunoglobulin Isotype-Switch Recombination, Immunoglobulin Switch Recombination, Switch Recombination 
Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh… Expand
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Review
2017
Review
2017
In order to promote an efficient humoral immune response, germinal center B cells modify both the antigen recognition and… Expand
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Review
2010
Review
2010
  • M. Lieber
  • Annual review of biochemistry
  • 2010
  • Corpus ID: 8437287
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous… Expand
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Highly Cited
2007
Highly Cited
2007
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo… Expand
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Highly Cited
2003
Highly Cited
2003
The mechanism responsible for immunoglobulin class switch recombination is unknown. Previous work has shown that class switch… Expand
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Highly Cited
2003
Highly Cited
2003
Activation-induced cytidine deaminase (AID) is a 'master molecule' in immunoglobulin (Ig) class-switch recombination (CSR) and… Expand
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Review
2003
Review
2003
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND We have previously proposed that deamination of cytosine to uracil at sites within the immunoglobulin loci by… Expand
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Highly Cited
2001
Highly Cited
2001
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain… Expand
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Highly Cited
2000
Highly Cited
2000
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation… Expand
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