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Immunoglobulin Class Switch Recombination

Known as: Immunoglobulin Isotype-Switch Recombination, Immunoglobulin Switch Recombination, Switch Recombination 
Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the… Expand
National Institutes of Health

Related topics

Related topics

4 relations
Cell Differentiation processImmune System ProcessesImmune responseb cell differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
T follicular helper cell heterogeneity: Time, space, and function
T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh… Expand
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Review
2017
Review
2017
Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination.
In order to promote an efficient humoral immune response, germinal center B cells modify both the antigen recognition and… Expand
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Review
2010
Review
2010
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
  • M. Lieber
  • Annual review of biochemistry
  • 2010
    • Corpus ID: 8437287
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous… Expand
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Highly Cited
2007
Highly Cited
2007
IgH class switching and translocations use a robust non-classical end-joining pathway
Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo… Expand
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Highly Cited
2003
Highly Cited
2003
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
The mechanism responsible for immunoglobulin class switch recombination is unknown. Previous work has shown that class switch… Expand
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Highly Cited
2003
Highly Cited
2003
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
Activation-induced cytidine deaminase (AID) is a 'master molecule' in immunoglobulin (Ig) class-switch recombination (CSR) and… Expand
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Review
2003
Review
2003
The regulation of immunoglobulin E class-switch recombination
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic… Expand
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Highly Cited
2002
Highly Cited
2002
Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice
BACKGROUND We have previously proposed that deamination of cytosine to uracil at sites within the immunoglobulin loci by… Expand
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Highly Cited
2001
Highly Cited
2001
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Class switch recombination (CSR) is a region-specific DNA recombination reaction that replaces one immunoglobulin heavy-chain… Expand
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Highly Cited
2000
Highly Cited
2000
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation… Expand
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