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Immunoglobulin Class Switch Recombination

Known as: Immunoglobulin Isotype-Switch Recombination, Immunoglobulin Switch Recombination, Switch Recombination 
Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the… 
National Institutes of Health

Related topics

Related topics

4 relations
Cell Differentiation processImmune System ProcessesImmune responseb cell differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Influence of switch region length on immunoglobulin class switch recombination.
The class and effector functions of antibodies are modulated through the process of Ig heavy chain class switch recombination… 
Highly Cited
2005
Highly Cited
2005
AID from bony fish catalyzes class switch recombination
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the… 
Highly Cited
2003
Highly Cited
2003
Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination
Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Sμ segments in… 
Highly Cited
2001
Highly Cited
2001
Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
The isotype specificity of immunoglobulin (Ig) class switching is regulated by a cytokine which induces transcription of a… 
Review
1999
Review
1999
Regulated genomic instability and neoplasia in the lymphoid lineage.
A DAPTIVE IMMUNITY in mammals depends on the generation of a vast repertoire of Ig and T-cell receptor (TCR) specificities… 
Highly Cited
1991
Highly Cited
1991
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.
H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of the specific switch region that will… 
Highly Cited
1990
Highly Cited
1990
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
Review
1986
Review
1986
Control of Immunoglobulin Class Switch Recombination
The comparative analysis of Ig class switch recombination in a priori IgG/IgA-expressing myelomas and hybridomas, in switch… 
Highly Cited
1982
Highly Cited
1982
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
Highly Cited
1982
Highly Cited
1982
Expression of lymphocyte surface IgE does not require switch recombination
Immunoglobin heavy (H) chains are composed of a variable (VH) and a constant (CH) region. The latter is encoded respectively by… 
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