Immunoglobulin Class Switch Recombination

Known as: Immunoglobulin Isotype-Switch Recombination, Immunoglobulin Switch Recombination, Switch Recombination 
Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the… (More)
National Institutes of Health

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4 relations
Cell Differentiation processImmune System ProcessesImmune responseb cell differentiation

Papers overview

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Highly Cited
2011
Highly Cited
2011
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.
53BP1 is a DNA damage protein that forms phosphorylated H2AX (γ-H2AX) dependent foci in a 1 Mb region surrounding DNA double… (More)
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Highly Cited
2010
Highly Cited
2010
PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for… (More)
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Review
2008
Review
2008
Mechanism and regulation of class switch recombination.
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a… (More)
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Highly Cited
2007
Highly Cited
2007
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks… (More)
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Highly Cited
2007
Highly Cited
2007
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
V(D)J recombination and immunoglobulin class switch recombination (CSR) are two somatic rearrangement mechanisms that proceed… (More)
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Highly Cited
2006
Highly Cited
2006
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
B cells producing high-affinity antibodies are destined to differentiate into memory B cells and plasma cells, but the mechanisms… (More)
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Highly Cited
2004
Highly Cited
2004
Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and… (More)
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Highly Cited
2004
Highly Cited
2004
An evolutionarily conserved target motif for immunoglobulin class-switch recombination
Immunoglobulin H class-switch recombination (CSR) occurs between switch regions and requires transcription and activation-induced… (More)
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Highly Cited
2003
Highly Cited
2003
Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
Activation-induced cytidine deaminase (AID) is a 'master molecule' in immunoglobulin (Ig) class-switch recombination (CSR) and… (More)
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Highly Cited
2000
Highly Cited
2000
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
Induced overexpression of AID in CH12F3-2 B lymphoma cells augmented class switching from IgM to IgA without cytokine stimulation… (More)
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