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Immunoglobulin Class Switch Recombination
Known as:
Immunoglobulin Isotype-Switch Recombination
, Immunoglobulin Switch Recombination
, Switch Recombination
Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the…
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National Institutes of Health
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Related topics
Related topics
4 relations
Cell Differentiation process
Immune System Processes
Immune response
b cell differentiation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Influence of switch region length on immunoglobulin class switch recombination.
Ali A. Zarrin
,
Ming Tian
,
Jing H. Wang
,
T. Borjeson
,
F. Alt
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 23104360
The class and effector functions of antibodies are modulated through the process of Ig heavy chain class switch recombination…
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Highly Cited
2005
Highly Cited
2005
AID from bony fish catalyzes class switch recombination
Vasco M. Barreto
,
Q. Pan-Hammarstrom
,
Yaofeng Zhao
,
Lennart Hammarstrom
,
Z. Misulovin
,
M. Nussenzweig
Journal of Experimental Medicine
2005
Corpus ID: 6834052
Class switch recombination was the last of the lymphocyte-specific DNA modification reactions to appear in the evolution of the…
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Highly Cited
2003
Highly Cited
2003
Mutations occur in the Ig Sμ region but rarely in Sγ regions prior to class switch recombination
C. E. Schrader
,
S. P. Bradley
,
Joycelyn Vardo
,
Sofia N. Mochegova
,
Erin Flanagan
,
J. Stavnezer
EMBO Journal
2003
Corpus ID: 21915753
Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Sμ segments in…
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Highly Cited
2001
Highly Cited
2001
Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
Chung-Gi Lee
,
K. Kinoshita
,
A. Arudchandran
,
S. Cerritelli
,
R. Crouch
,
T. Honjo
Journal of Experimental Medicine
2001
Corpus ID: 2103088
The isotype specificity of immunoglobulin (Ig) class switching is regulated by a cytokine which induces transcription of a…
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Review
1999
Review
1999
Regulated genomic instability and neoplasia in the lymphoid lineage.
G. Vanasse
,
Patrick Concannon
,
D. Willerford
Blood
1999
Corpus ID: 39061014
A DAPTIVE IMMUNITY in mammals depends on the generation of a vast repertoire of Ig and T-cell receptor (TCR) specificities…
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Highly Cited
1991
Highly Cited
1991
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.
P. Shockett
,
J. Stavnezer
Journal of Immunology
1991
Corpus ID: 2504069
H chain isotype switch recombination is preceded by the appearance of RNA initiating 5' of the specific switch region that will…
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Highly Cited
1990
Highly Cited
1990
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
R. Gerstein
,
W. Frankel
,
+5 authors
E. Selsing
Cell
1990
Corpus ID: 46055563
Review
1986
Review
1986
Control of Immunoglobulin Class Switch Recombination
Andreas Radbruch
,
C. Burger
,
S. Klein
,
Werner Müller
Immunological Reviews
1986
Corpus ID: 43691214
The comparative analysis of Ig class switch recombination in a priori IgG/IgA-expressing myelomas and hybridomas, in switch…
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Highly Cited
1982
Highly Cited
1982
Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.
T. Nikaido
,
Y. Yamawaki‐Kataoka
,
T. Honjo
Journal of Biological Chemistry
1982
Corpus ID: 24471055
Highly Cited
1982
Highly Cited
1982
Expression of lymphocyte surface IgE does not require switch recombination
Y. Yaoita
,
Y. Kumagai
,
K. Okumura
,
T. Honjo
Nature
1982
Corpus ID: 4336213
Immunoglobin heavy (H) chains are composed of a variable (VH) and a constant (CH) region. The latter is encoded respectively by…
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