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Defective mitochondrial quality control is shown to be a mechanism for neurodegeneration in some forms of Parkinson's disease.
Microtubule-associated protein light chain 3 (LC3) is now widely used to monitor autophagy. One approach is to detect LC3… Expand Context The Third National Health and Nutrition Examination Survey (NHANES III), conducted between 1988 and 1994, indicated that… Expand BACKGROUND
Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis distinct from other forms of human prion disease: disease… Expand The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in synaptosomal high‐affinity glutamate… Expand The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown mechanism. Here we demonstrate that a… Expand NADPH diaphorase histochemistry selectively labels a number of discrete populations of neurons throughout the nervous system… Expand A tight junction-enriched membrane fraction has been used as immunogen to generate a monoclonal antiserum specific for this… Expand We have determined the biochemical and immunocytochemical localization of the heterogeneous microtubule-associated protein tau… Expand A murine monoclonal antibody specific for calf intestinal alkaline phosphatase has been prepared and used in an unlabeled… Expand