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Idarubicin

Known as: Idarubicin [Chemical/Ingredient], 4 Desmethoxydaunorubicin, (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside 
A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes… 
National Institutes of Health

Related topics

Related topics

44 relations
10 ML Idarubicin Hydrochloride 1 MG/ML InjectionAIE RegimenAnthracyclinesCOG-C9710 APL Regimen

Narrower (23)

13-methyl-13-dihydro-4-demethoxydaunorubicin4-demethoxy-10,10-dimethyldaunomycin4-demethoxy-11-deoxydaunomycin4-demethoxydaunomycinone

Broader (1)

Antibiotics, Antineoplastic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia.
Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we… 
Highly Cited
2002
Highly Cited
2002
Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats.
Idarubicin-loaded solid lipid nanoparticles (IDA-SLN) and idarubicin in solution were prepared and the two formulations were… 
Review
2001
Review
2001
Anthracycline-induced cardiomyopathy.
Review
1987
Review
1987
Therapy of acute myelogenous leukemia.
  • Gale RpFoon Ka
  • Seminars in hematology (Print)
  • 1987
  • Corpus ID: 222266406
Over the past 10 years, there have been substantial advances in the treatment of AML. Intensive induction chemotherapy using 7… 
Highly Cited
1983
Highly Cited
1983
Stimulation of mouse heart and liver microsomal lipid peroxidation by anthracycline anticancer drugs: characterization and effects of reactive oxygen scavengers.
The interaction of adriamycin or several other quinone-containing anthracycline anticancer drugs with mouse heart or liver… 
Highly Cited
1983
Highly Cited
1983
Phase I and clinical pharmacology studies of intravenous and oral administration of 4-demethoxydaunorubicin in patients with advanced cancer.
4-Demethoxydaunorubicin (4-DMDR), an anthracycline analogue available in i.v. and p.o. form, has shown significant antitumor… 
Highly Cited
1980
Highly Cited
1980
Antileukemic Activity of 4-Demethoxydaunorubicin in Mice
4-demethoxydaunorubicin was tested against experimental mouse leukemias, in comparison with doxorubicin and daunorubicin. 4… 
Highly Cited
1977
Highly Cited
1977
Relationship between effects on nucleic acid synthesis in cell cultures and cytotoxicity of 4-demethoxy derivatives of daunorubicin and adriamycin.
Four new derivatives of daunorubicin and two new derivatives of Adriamycin characterized by the absence of the methoxyl groups at… 
Highly Cited
1976
Highly Cited
1976
Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers.
Four new derivatives of daunorubicin, characterized by the absence of the methoxyl group at the C-4 position, have been obtained… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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