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Idarubicin

Known as: Idarubicin [Chemical/Ingredient], 4 Desmethoxydaunorubicin, (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside 
A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes… 
National Institutes of Health

Related topics

Related topics

44 relations
10 ML Idarubicin Hydrochloride 1 MG/ML InjectionAIE RegimenAnthracyclinesCOG-C9710 APL Regimen

Narrower (23)

13-methyl-13-dihydro-4-demethoxydaunorubicin4-demethoxy-10,10-dimethyldaunomycin4-demethoxy-11-deoxydaunomycin4-demethoxydaunomycinone

Broader (1)

Antibiotics, Antineoplastic

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
The Price and Purity of Illicit Drugs: 1981-2007
Abstract : This paper updates estimates of the price and purity of selected illicit drugs (powder cocaine, crack cocaine, heroin… 
Highly Cited
2003
Highly Cited
2003
Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia.
Based on our previous demonstration that quinine could be used clinically to reverse P-glycoprotein-mediated resistance, we… 
Highly Cited
2000
Highly Cited
2000
Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells.
Highly Cited
1989
Highly Cited
1989
Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines in a model of doxorubicin-sensitive and -resistant rat glioblastoma cells.
Highly Cited
1985
Highly Cited
1985
Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia.
Fifty-two adults treated previously with either acute leukemia (43 patients) or blastic-phase chronic myelogenous leukemia (nine… 
Highly Cited
1984
Highly Cited
1984
Activity and distribution of iv and oral 4-demethoxydaunorubicin in murine experimental tumors.
The antitumor activity of 4-demethoxydaunorubicin ( 4DDM ) compared to its parent compound daunorubicin (DM) was investigated in… 
Highly Cited
1983
Highly Cited
1983
Phase I and clinical pharmacology studies of intravenous and oral administration of 4-demethoxydaunorubicin in patients with advanced cancer.
4-Demethoxydaunorubicin (4-DMDR), an anthracycline analogue available in i.v. and p.o. form, has shown significant antitumor… 
Highly Cited
1977
Highly Cited
1977
Antitumor activity of 4-demethoxydaunorubicin administered orally.
Highly Cited
1966
Highly Cited
1966
Episome-carried surface antigen K88 of Escherichia coli. I. Transmission of the determinant of the K88 antigen and influence on the transfer of chromosomal markers.
Ørskov, Ida (Statens Seruminstitut, Copenhagen, Denmark), and Frits Ørskov. Episome-carried surface antigen K88 of Escherichia… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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