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Idarubicin
Known as:
Idarubicin [Chemical/Ingredient]
, 4 Desmethoxydaunorubicin
, (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside
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A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes…
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National Institutes of Health
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Related topics
Related topics
44 relations
10 ML Idarubicin Hydrochloride 1 MG/ML Injection
AIE Regimen
Anthracyclines
COG-C9710 APL Regimen
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Narrower (23)
13-methyl-13-dihydro-4-demethoxydaunorubicin
4-demethoxy-10,10-dimethyldaunomycin
4-demethoxy-11-deoxydaunomycin
4-demethoxydaunomycinone
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Broader (1)
Antibiotics, Antineoplastic
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1985
Highly Cited
1985
Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia.
A. Daghestani
,
Z. Arlin
,
+7 authors
L. Williams
Cancer Research
1985
Corpus ID: 21015056
Fifty-two adults treated previously with either acute leukemia (43 patients) or blastic-phase chronic myelogenous leukemia (nine…
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1984
1984
Structure-activity relationship of anthracycline-induced genotoxicity in vitro.
J. Westendorf
,
H. Marquardt
,
H. Marquardt
Cancer Research
1984
Corpus ID: 21959605
Anthracycline antitumor antibiotics, such as Adriamycin and daunomycin, are potent genotoxic agents and carcinogens. A variety of…
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Highly Cited
1983
Highly Cited
1983
Phase I and clinical pharmacology studies of intravenous and oral administration of 4-demethoxydaunorubicin in patients with advanced cancer.
E. Berman
,
R. Wittes
,
+6 authors
C. Young
Cancer Research
1983
Corpus ID: 6976190
4-Demethoxydaunorubicin (4-DMDR), an anthracycline analogue available in i.v. and p.o. form, has shown significant antitumor…
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1983
1983
Filling, postcholecystokinin emptying, and refilling of normal gallbladder: effects of two different doses of CCK on refilling: concise communication.
M. Mesgarzadeh
,
G. T. Krishnamurthy
,
V. Bobba
,
K. Langrell
Journal of Nuclear Medicine
1983
Corpus ID: 1587063
A study of 18 normal subjects was undertaken to evaluate the rapidity of gallbladder filling with Tc-99m IDA during fast, and the…
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1983
1983
Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines.
S. Penco
,
A. Casazza
,
+8 authors
F. Arcamone
Cancer treatment reports
1983
Corpus ID: 21292359
The new anthracycline glycosides 4-demethoxy-4'-deoxydaunorubicin and 4-demethoxy-4'-O-methyldaunorubicin, synthesized by…
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Highly Cited
1980
Highly Cited
1980
Cytofluorescence localization of anthracycline antibiotics.
M. Egorin
,
R. Clawson
,
J. Cohen
,
L. A. Ross
,
N. Bachur
Cancer Research
1980
Corpus ID: 5181994
Previous fluorescence microscopic studies have shown daunorubicin (DNR) and Adriamycin (ADR) are localized in cell nuclei…
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1979
1979
Quantitative models for growth inhibition of human leukemia cells by antitumor anthracycline derivatives.
P. Kanter
,
H. S. Schwartz
Cancer Research
1979
Corpus ID: 27011367
A batch elution method with hydroxylapatite was developed to assay DNA damage by a set of antitumor anthracycline derivatives and…
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1978
1978
Experimental and clinical trials of new 99mTc-labeled hepatobiliary agents.
B. W. Wistow
,
G. Gagne
,
R. Henderson
,
J. McAfee
,
R. Hall
,
Z. Grossman
Radiology
1978
Corpus ID: 45079186
Several new derivatives of lidocaine were synthesized and used to examine the intra- and extrahepatic bile ducts and gallbladder…
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Highly Cited
1977
Highly Cited
1977
Antitumor activity of 4-demethoxydaunorubicin administered orally.
A. Di Marco
,
A. Casazza
,
G. Pratesi
Cancer treatment reports
1977
Corpus ID: 13382403
Highly Cited
1947
Highly Cited
1947
DISEASE
R. Baggott
Social Policy & Administration
1947
Corpus ID: 222064452
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic…
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