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ITGA5 protein, human

Known as: VLA5, CD49 Antigen-Like Family Member E, Integrin Alpha-5 
Integrin alpha-5 (1049 aa, ~115 kDa) is encoded by the human ITGA5 gene. This protein plays a role in cell-matrix adhesion.
National Institutes of Health

Related topics

Related topics

11 relations
Cell AdhesionClusters of differentiationFocal adhesion pathwayGlycoproteins

Broader (1)

Integrin alpha5

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
miR148b is a major coordinator of breast cancer progression in a relapse‐associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we… 
Highly Cited
2010
Highly Cited
2010
Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea.
Endothelial dysfunction is involved in vascular complications of obstructive sleep apnea (OSA). In this study, circulating… 
Highly Cited
2009
Highly Cited
2009
Priming integrin α5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis
Adult human mesenchymal stromal cells (hMSCs) have the potential to differentiate into chondrogenic, adipogenic, or osteogenic… 
Highly Cited
2001
Highly Cited
2001
Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system.
Keratinocyte growth factor (KGF) is a paracrine mediator of epithelial cell growth. To examine the direct effects of KGF on the… 
Highly Cited
1994
Highly Cited
1994
Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5
Extracellular matrix (ECM) molecules such as fibronectin (FN), collagens, and laminin have important roles in hematopoiesis… 
Highly Cited
1993
Highly Cited
1993
Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin
We report that a beta 1 integrin (alpha 5 beta 1) can exist in different affinity states for its soluble ligand, fibronectin. The… 
Highly Cited
1991
Highly Cited
1991
Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.
Growth of anchorage-dependent cells requires both soluble mitogens and insoluble extracellular matrix molecules such as… 
Highly Cited
1991
Highly Cited
1991
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.
Highly Cited
1991
Highly Cited
1991
Multiple integrins share the ability to induce elevation of intracellular pH.
Highly Cited
1989
Highly Cited
1989
Changes in integrin receptors on oncogenically transformed cells
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