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Polysialic acid: Biosynthesis, novel functions and applications
TLDR
Bacterial polysialyltransferases are more promiscuous than the protein-specific mammalian enzymes, and new studies suggest that these enzymes have tremendous therapeutic potential, especially for strategies aimed at neural regeneration and tissue repair.
A newly identified zona pellucida glycoprotein, ZPD, and dimeric ZP1 of chicken egg envelope are involved in sperm activation on sperm-egg interaction.
TLDR
Another 42 kDa protein, designated ZPD, has been found as a new major component of the chicken egg envelope and might bind loosely to egg envelope matrix and play a key role in the sperm activation on avian sperm-egg interaction.
Disialic, oligosialic and polysialic acids: distribution, functions and related disease.
Sialic acids (Sia) are involved in many biological activities and frequently exist as monosialyl residues at the non-reducing terminal end of glycoconjugates. Occasionally, polymerized structures in
Endo-β-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol
TLDR
The identification of the gene encoding human cytosolic ENGase, a key enzyme involved in the processing of free oligosaccharides in the cytosol, was reported, suggesting that this enzyme is involved in basic biological processes in eukaryotic cells.
KDN (Deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family
TLDR
The 20 years history of studies on KDN (KDNology), through which KDN has established its position as a distinct member of the sialic acid family, is described and future perspective of KDNology is presented.
A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian Zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific
TLDR
A glycoprotein with molecular mass of 42 kDa was identified as the major component of the chicken egg-envelope, the filamentous, extracellular matrix known as the perivitelline layer, and was found to be accumulated in granulosa cells in a manner dependent on ovarian follicular development.
Novel Regulation of Fibroblast Growth Factor 2 (FGF2)-mediated Cell Growth by Polysialic Acid*
TLDR
Results suggest that polySia-NCAM might be involved in the regulation of F GF2-FGF receptor signaling through the direct binding of FGF2 in a manner distinct from heparan sulfate.
Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles.
TLDR
A possible role of MFG-E8 in the membrane vesicle secretion, such as budding or shedding of plasma membrane (microvesicles) and exocytosis of endocytic multivesicular bodies (exosomes) is suggested.
Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8.
TLDR
The results suggest that the alternative splicing plays a critical role for the mammary-specific and lactation-dependent expression of the MFG-E8 isoform and that the multiply O-glycosylated Pro/Thr-rich domain of this isoform is functionally important for formation of milk fat globules in mammary epithelial cells.
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