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Sialylation is essential for early development in mice
- M. Schwarzkopf, K. Knobeloch, R. Horstkorte
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 2 April 2002
It is reported that inactivation of the UDP-GlcNAc 2-epimerase by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development.
Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway.
- Kaya Bork, R. Horstkorte, Wenke Weidemann
- Biology, ChemistryJournal of pharmaceutical sciences
- 1 October 2009
Sialylation of over-expressed glycoproteins in all mammalian cell lines commonly used in biotechnology for the production of therapeutic glycoprotein is incomplete and there is a need for strategies leading to homogenous, naturally sialylated glyCoproteins.
The neural cell adhesion molecule is associated with major components of the cytoskeleton.
Evidence for Cis Interaction and Cooperative Signalling by the Heat‐stable Antigen Nectadrin (murine CD24) and the Cell Adhesion Molecule L1 in Neurons
- G. Kadmon, F. Halbach, R. Horstkorte, M. Eckert, P. Altevogt, M. Schachner
- BiologyThe European journal of neuroscience
- 1 May 1995
Nectadrin is co‐expressed with L1 in murine cerebellar granule cell neurons and neuroblastoma N2A cells and appears to join a functional complex of neuronal adhesion molecules and to potentiate the signal transduction pathway of L1, possibly in response to neuron‐neuron contact formation.
Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A.
This study identified novel intracellular binding partners of NCAM 140 and NCAM 180 by peptide mass fingerprinting Western blot analysis and showed that binding of these novel binding proteins, as well as the previously described interaction partners ROK alpha and alpha- and beta-tubulin, bind to specific cytosolic sequences ofNCAM.
The intracellular concentration of sialic acid regulates the polysialylation of the neural cell adhesion molecule
Cytoplasmic domain of NCAM 180 reduces NCAM‐mediated neurite outgrowth
It is demonstrated that membrane‐associated NCAM 180 interferes with neurite outgrowth, whereas membrane‐ associated NCAM 140 promotes neuriteOutgrowth.
Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression.
- Wenke Weidemann, C. Klukas, A. Klein, A. Simm, F. Schreiber, R. Horstkorte
- Biology, ChemistryGlycobiology
It is found for the first time that proliferation is directly correlated with GNE-expression and the cellular sialic acid concentration, and identified growth-related genes that are differentially expressed in G NE-deficient embryonic stem cells compared to wild-type embryonic stem Cells.
Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells.