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ITCH gene

Known as: itchy E3 ubiquitin protein ligase, ITCHY E3 UBIQUITIN PROTEIN LIGASE, MOUSE, HOMOLOG OF, AIP4 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure
Mutations in the ITCH gene can cause severe SMAD, which is a possible cause of acute liver failure requiring an LT. Pediatric… 
2018
2018
Ubiquitin‐ligase AIP4 controls differential ubiquitination and stability of isoforms of the scaffold protein ITSN1
At present, the role of ubiquitination of cargoes internalized from the plasma membrane is better understood than the… 
2013
2013
Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display.
2010
2010
Abstract 3687: Expression of a Src-family kinase in CML cells induces resistance to imatinib in a kinase-dependent manner
Chronic Myelogenous Leukemia (CML) is characterized by the presence of Philadelphia Chromosome, which results in the expression… 
2008
2008
Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV.
2008
2008
Mécanismes de régulation de la protéine TGIF
Le TGIF (TG Interacting Factor) est un represseur de differents facteurs transcriptionnels qui sont impliques dans la… 
Review
2005
Review
2005
RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation.
2005
2005
The Epstein-Barr Virus Protein, Latent Membrane Protein 2A, Co-opts Tyrosine Kinases Used by the T Cell Receptor*
Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis and is associated with several human malignancies… 
Highly Cited
2003
Highly Cited
2003
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
Whether the apparent efficacy of a specific kinase inhibitor is attributable solely to inhibition of its primary target, or to… 
Highly Cited
2003
Highly Cited
2003
Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling
ABSTRACT Nedd4 family ubiquitin protein ligases (E3s) specifically associate with latent membrane protein 2A (LMP2A) of Epstein… 
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