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Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs
- S. Kosugi, Masako Hasebe, M. Tomita, H. Yanagawa
- BiologyProceedings of the National Academy of Sciences
- 23 June 2009
The successful prediction of CDK1-regulated nucleocytoplasmic shuttling proteins is reported using a prediction system for nuclear localization signals (NLSs) and the application of this strategy to other functional linear motifs should be useful in systematic studies of protein–protein networks.
Six Classes of Nuclear Localization Signals Specific to Different Binding Grooves of Importin α*
Six different NLS classes that specifically bind to distinct binding pockets of importin α are reported, finding that they fundamentally require the regions outside the core basic residues for their activity and have specific residues or patterns that confer the activities differently between yeast, plants, and mammals.
Design of peptide inhibitors for the importin alpha/beta nuclear import pathway by activity-based profiling.
Design of generic biosensors based on green fluorescent proteins with allosteric sites by directed evolution
Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells.
It is found that CD44, a cell surface marker for cancer stem cells, interacts with pyruvate kinase M2 (PKM2) and thereby enhances the glycolytic phenotype of cancer cells that are either deficient in p53 or exposed to hypoxia.
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
The results indicate that cellular states are constrained by complex networks involving both positive and negative regulatory interactions among substantial numbers of transcription factors and that no single transcription factor is both necessary and sufficient to drive the differentiation process.
Metabolic Engineering of Carotenoid Biosynthesis in Escherichia coli by Ordered Gene Assembly in Bacillus subtilis
- T. Nishizaki, K. Tsuge, M. Itaya, N. Doi, H. Yanagawa
- Biology, EngineeringApplied and Environmental Microbiology
- 28 December 2006
The results suggest that rearrangement of biosynthetic genes in the order of the metabolic pathway by the OGAB method could be a useful approach for metabolic engineering.
Cleavage of double-stranded RNA by RNase HI from a thermoacidophilic archaeon, Sulfolobus tokodaii 7.
Similarities in primary structure and biochemical characteristics between S.tokodaii RNase HI and reverse transcriptases imply that the S.kodaii enzyme might be derived from the RNase H domain of reverse transcriptase.
Nuclear Export Signal Consensus Sequences Defined Using a Localization‐Based Yeast Selection System
An efficient yeast selection system for detecting nuclear export activity as well as several reliable NES consensus sequences identified using this method are reported, which should help identify functional NESs.