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IRF3 protein, human

Known as: IRF-3, Interferon Regulatory Factor 3, IRF3 
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral… 
National Institutes of Health

Related topics

Related topics

10 relations
Antiviral ResponseDNA-Binding ProteinsGenes, RegulatorIRF3 gene

Broader (1)

Interferon Regulatory Factor 3

Papers overview

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Highly Cited
2013
Highly Cited
2013
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial… 
Highly Cited
2013
Highly Cited
2013
IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I interferon (IFN) induction and IFN… 
Highly Cited
2008
Highly Cited
2008
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Review
2007
Review
2007
Triggering the Innate Antiviral Response through IRF-3 Activation*
Rapid induction of type I interferon (IFN) expression is a central event in the establishment of the innate immune response… 
Highly Cited
2007
Highly Cited
2007
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory… 
Highly Cited
2006
Highly Cited
2006
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1… 
Highly Cited
2005
Highly Cited
2005
Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3
ABSTRACT Rabies virus (RV) of the Rhabdoviridae family grows in alpha/beta interferon (IFN)-competent cells, suggesting the… 
Highly Cited
2004
Highly Cited
2004
A FADD-dependent innate immune mechanism in mammalian cells
Vertebrate innate immunity provides a first line of defence against pathogens such as viruses and bacteria. Viral infection… 
Highly Cited
1998
Highly Cited
1998
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
Highly Cited
1998
Highly Cited
1998
Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1
ABSTRACT Cells respond to viral infection or double-stranded RNA with the transcriptional induction of a subset of alpha/beta… 
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