Skip to search formSkip to main contentSkip to account menu

IRF3 protein, human

Known as: IRF-3, Interferon Regulatory Factor 3, IRF3 
Interferon regulatory factor 3 (427 aa, ~47 kDa) is encoded by the human IRF3 gene. This protein plays a role in the modulation of both antiviral… 
National Institutes of Health

Related topics

Related topics

10 relations
Antiviral ResponseDNA-Binding ProteinsGenes, RegulatorIRF3 gene

Broader (1)

Interferon Regulatory Factor 3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF-κB than Type I IFNs
ABSTRACT Interferons (IFNs) are induced as an initial response to viral infection after recognition of pathogen-associated… 
Highly Cited
2009
Highly Cited
2009
Activation of Toll-like receptor 3 augments myofibroblast differentiation.
Airway remodeling is observed in the airways of patients with asthma, and differentiation of fibroblasts to myofibroblasts plays… 
Highly Cited
2007
Highly Cited
2007
Involvement of TBK1 and IKKϵ in lipopolysaccharide‐induced activation of the interferon response in primary human macrophages
Interferon (IFN) is an important effector of the innate immune response, induced by different viral or bacterial components… 
Highly Cited
2006
Highly Cited
2006
Differential Activation of IFN Regulatory Factor (IRF)-3 and IRF-5 Transcription Factors during Viral Infection1
Members of the IFN regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and… 
Highly Cited
2006
Highly Cited
2006
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
The induction of type I interferon (IFN) and the development of the innate antiviral response are mediated by the activation of… 
Highly Cited
2006
Highly Cited
2006
Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation1
Activation of the innate arm of the immune system following pathogen infection relies on the recruitment of latent transcription… 
Highly Cited
2006
Highly Cited
2006
Human Cytomegalovirus IE86 Attenuates Virus- and Tumor Necrosis Factor Alpha-Induced NFκB-Dependent Gene Expression
ABSTRACT Human cytomegalovirus (HCMV) infection regulates a number of genes involved in the host antiviral response. We have… 
Highly Cited
2006
Highly Cited
2006
Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection
ABSTRACT Hepatitis C virus (HCV) infection induces the α-chemokine interleukin-8 (CXCL-8), which is regulated at the levels of… 
2003
2003
Oncogenic Potential of a Dominant Negative Mutant of Interferon Regulatory Factor 3*
Interferon regulatory factor 3 (IRF3) is activated in response to various environmental stresses including viral infection and… 
Highly Cited
2002
Highly Cited
2002
Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
ABSTRACT Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)