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IRF2 wt Allele

Known as: IRF-2, Interferon Regulatory Factor 2 wt Allele 
Human IRF2 wild-type allele is located within 4q34.1-q35.1 and is approximately 87 kb in length. This allele, which encodes interferon regulatory… 
National Institutes of Health

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Homo sapiensIRF2 protein, humanInterferon Regulatory Factor 2Transcriptional Activation

Broader (1)

IRF2 gene

Papers overview

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2010
2010
The role for interferon regulatory factor-2 on mouse hematopoietic stem cells in an inflammation state
Megakaryopoiesis is associated with inflammation, and certain inflammatory cytokines stimulate hematopoietic progenitors to… 
2008
2008
Regulation of the murine TR2/HVEM gene expression by IRF.
2007
2007
IFN Regulatory Factor-2 Regulates Macrophage Apoptosis through a STAT1/3- and Caspase-1-Dependent Mechanism1
IFN regulatory factor (IRF)-2−/− mice are significantly more resistant to LPS challenge than wild-type littermates, and this was… 
2002
2002
Interferon regulatory factor-1 mediates interferon-gamma-induced apoptosis in ovarian carcinoma cells.
Interferon-gamma (IFN-gamma), as one of interferon family that regulates antiviral, antiproliferative, and immunomodulatory… 
2002
2002
The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro
Cyclooxygenase (COX) exists as two isoforms: COX-1, which is constitutively expressed in most cell types; and COX-2, which is… 
2000
2000
Cloning of an interferon regulatory factor 2 isoform with different regulatory ability.
Interferons (IFNs) are a family of multifunctional proteins involved in immune activation, regulation of cell growth and… 
2000
2000
An IFN regulatory factor-2 DNA-binding domain dominant negative mutant exhibits altered cell growth and gene expression
In order to study interferon regulatory factor (IRF) family mediation of cell growth regulation, we established U937 cell lines… 
Highly Cited
1996
Highly Cited
1996
Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes.
Recent studies have reported that IFN regulatory factor-1 (IRF-1) regulates nitric oxide (NO.) production in murine macrophages… 
Highly Cited
1995
Highly Cited
1995
The Growth-dependent Expression of Angiotensin II Type 2 Receptor Is Regulated by Transcription Factors Interferon Regulatory Factor-1 and −2 (*)
Angiotensin II type 2 (AT2) receptor is abundantly and widely expressed in fetal tissues but present only in restricted tissues… 
Highly Cited
1995
Highly Cited
1995
Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.
The Interferon Regulatory Factors-1 and -2 (IRF-1 and IRF-2) play a transcriptional role in the regulation of the IFN-beta gene… 
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