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IPI-145
Known as:
PI3K delta/gamma Inhibitor IPI-145
An orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (2)
Isoquinolines
Purines
NCIt Antineoplastic Agent Terminology
Narrower (1)
duvelisib
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Novel Therapies for Chronic Lymphocytic Leukemia: A Canadian Perspective.
C. Owen
,
S. Assouline
,
J. Kuruvilla
,
C. Uchida
,
C. Bellingham
,
L. Sehn
Clinical Lymphoma, Myeloma & Leukemia
2015
Corpus ID: 206819099
2015
2015
Combination Trial of Duvelisib (IPI-145) with Bendamustine, Rituximab, or Bendamustine/Rituximab in Patients with Lymphoma or Chronic Lymphocytic Leukemia
I. Flinn
,
M. Cherry
,
M. Maris
,
J. Matous
,
J. Berdeja
,
M. Patel
2015
Corpus ID: 78578211
Background: Duvelisib, a potent inhibitor of the δ and γ isoforms of phosphoinositide-3-kinase (PI3K) is being developed as a…
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2014
2014
Duvelisib (IPI-145), a Phosphoinositide-3-Kinase-δ,γ Inhibitor, Shows Activity in Patients with Relapsed/Refractory T-Cell Lymphoma
S. Horwitz
,
P. Porcu
,
+7 authors
F. Foss
2014
Corpus ID: 208449324
Introduction: Peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL) are uncommon lymphoid malignancies. Approved…
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2014
2014
Novel Phosphoinositide 3-Kinase d , g Inhibitor: Potent Anti-Inflammatory Effects and Joint Protection in Models of Rheumatoid Arthritis
D. Boyle
,
Hae-Rim Kim
,
Katharyn Topolewski
,
B. Bartok
,
G. Firestein
2014
Corpus ID: 14359960
Phosphoinositide 3-kinases g and d (PI3K g and PI3K d ) are expressed in rheumatoid arthritis (RA) synovium and regulate innate…
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Review
2014
Review
2014
Phosphoinositide 3-kinase inhibitors in lymphoma
E. Curran
,
Sonali M. Smith
Current Opinion in Oncology
2014
Corpus ID: 205546084
Purpose of review The phosphoinositide 3-kinase (PI3K) pathway, with downstream targets including Akt and mammalian target of…
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2013
2013
Preliminary safety and efficacy of IPI-145, a potent inhibitor of phosphoinositide-3-kinase-δ,γ, in patients with relapsed/refractory lymphoma.
S. Horwitz
,
I. Flinn
,
+8 authors
B. Kahl
2013
Corpus ID: 220663217
7070 Background: Phosphoinositide-3-kinases (PI3Ks) are pivotal in cell signaling and regulate a variety of cellular functions…
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2013
2013
Preliminary Safety and Efficacy Of IPI-145, a Potent Inhibitor Of Phosphoinositide-3-Kinase-δ,γ, In Patients With Chronic Lymphocytic Leukemia
M. Patel
,
B. Kahl
,
+11 authors
S. O'brien
2013
Corpus ID: 74641107
Introduction IPI-145 is an oral, potent PI3K-δ,γ inhibitor currently in development for the treatment of hematologic (heme…
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2013
2013
The Potent PI3K-δ,γ Inhibitor IPI-145 Exhibits Differential Activity In Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines
V. Campbell
,
Ryan Thompson
,
+4 authors
H. Stern
2013
Corpus ID: 67982818
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma (NHL). Despite aggressive…
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2013
2013
The Potent PI3K-δ,γ Inhibitor, IPI-145, Exhibits Preclinical Activity In Murine and Human T-Cell Acute Lymphoblastic Leukemia
Xiao-Hang Huang
,
J. Proctor
,
+7 authors
M. J. You
2013
Corpus ID: 89055080
Phosphoinositide-3 kinases (PI3Ks) are key cellular signaling proteins that act as a central node for relaying signals from cell…
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2013
2013
Treatment With The Potent PI3K-δ,γ Inhibitor IPI-145 Is Associated With Rapid Decreases In Specific Cytokines, Chemokines and Matrix Metalloproteinases In The Serum Of Patients With Chronic…
M. Douglas
,
K. Allison
,
+6 authors
H. Stern
2013
Corpus ID: 79453146
Phosphoinositide-3 kinases (PI3Ks) are key cellular signaling proteins that act as a central node, relaying signals from cell…
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