duvelisib
National Institutes of Health
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Phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitously distributed lipid kinases that control a wide variety of…
Introduction:
Duvelisib (DUV), an oral inhibitor of PI3K-δ/γ, and venetoclax (VEN), an oral inhibitor of BCL-2, are both…
Epstein–Barr virus (EBV) is a ubiquitous oncogenic virus that is associated with B cell lymphomas, including Burkitt lymphoma and…
37.5% with 4 CRs (25%) in ABC patient. Response to copanlisib was 25% in pts with (2/8) and without (8/32) CD79B mutations. Five…
Background: Mantle cell lymphoma (MCL) is an incurable subtype of B-cell lymphoma. Ibrutinib, a first-in-class, once-daily, oral…
Background: Duvelisib, a potent inhibitor of the δ and γ isoforms of phosphoinositide-3-kinase (PI3K) is being developed as a…
Background: FCR remains the gold standard for the initial treatment of younger patients with CLL, yet only about 20% of patients…
8559 Background: Signaling via PI3K-δ and PI3K-γ has distinct and complementary effects on the tumor cell/ tumor microenvironment…
Introduction: Peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL) are uncommon lymphoid malignancies. Approved…