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IL22 wt Allele

Known as: MGC79382, IL21, MGC79384 
Human IL22 wild-type allele is located in the vicinity of 12q15 and is approximately 5 kb in length. This allele, which encodes interleukin-22, plays… 
National Institutes of Health

Related topics

Related topics

8 relations
12q15Cell Proliferation Regulatory ProcessCytokine Receptor BindingCytokine Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Diversifying selection signatures among divergently selected subpopulations of Polish Red cattle
Polish Red cattle is one of the few indigenous breeds of European red cattle which is characterized by several desired features… 
2014
2014
Decrease in serum interleukin-21 levels is associated with disease activity improvement in patients with recent-onset rheumatoid arthritis.
Interleukin-21 (IL-21) plays an important role in the pathogenesis of rheumatoid arthritis (RA). The aim of our study was to… 
Highly Cited
2013
Highly Cited
2013
Follicular Helper T Cells (Tfh) and IL-21 Involvement in the Pathogenesis of Bullous Pemphigoid
The pathogenesis of bullous pemphigoid (BP) is characterized by the T cell-dependent production of autoantibodies. Recent studies… 
2013
2013
In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells.
IL-21, a member of the IL-2 cytokine family, is mainly produced by activated CD4(+) T cells and controls the activity of immune… 
2012
2012
Cerebrospinal Fluid IL-21 Levels in Neuromyelitis Optica and Multiple Sclerosis
Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central… 
Highly Cited
2011
Highly Cited
2011
Increase in Th17 and T-reg Lymphocytes and Decrease of IL22 Correlate with the Recovery Phase of Acute EAE IN Rat
Experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis, is characterised by microglial… 
2011
2011
Genome-wide analysis of extended pedigrees confirms IL2-IL21 linkage and shows additional regions of interest potentially influencing coeliac disease risk.
Coeliac disease is a chronic inflammatory condition of the small intestine, triggered by dietary exposure to gluten in… 
Review
2011
Review
2011
IL-21 and Related Diseases
IL-21, which is produced by activated NKT cells and CD4+ T cells, exhibits pleiotropic effects not only on a variety of immune… 
Highly Cited
2005
Highly Cited
2005
IL-21 Enhances Tumor Rejection through a NKG2D-Dependent Mechanism1
IL-21 is a cytokine that can promote the anti-tumor responses of the innate and adaptive immune system. Mice treated with IL-21… 
2005
2005
IL-21 Improves Rituximab-Mediated B Cell Depletion.
IL-21 is a cytokine produced by activated CD4+ T cells that augments the growth, survival, and function of NK, T and phagocytic… 
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