• Publications
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Comparison of the immunogenicity and safety of Cervarix™ and Gardasil® human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18–45 years
In the total vaccinated cohort (all women who received at least one vaccine dose, regardless of their serological and DNA status prior to vaccination), Cervarix™ induced significantly higher serum neutralizing antibody titers in all age strata. Expand
Rationale for pertussis booster vaccination throughout life in Europe.
Recommendations for use of pertussis booster vaccinations at different ages are proposed to reduce individual morbidity and transmission from present rates and increase herd protection. Expand
Principles of vaccine design-Lessons from nature.
  • F. Zepp
  • Medicine, Biology
  • Vaccine
  • 31 August 2010
Improved knowledge of immune response mechanisms has brought successes in the development of vaccines that protect against challenging pathogens as well as vaccines that can be used in immunocompromised and elderly populations, which has opened up the potential of extending its application in immunotherapies to tackle diseases such as cancer, Alzheimer disease and immune-mediated disorders. Expand
Ten years’ experience with year-round active surveillance of up to 19 respiratory pathogens in children
Active surveillance systems for ARI in children in Germany are superior to passive systems and should be pathogen-specific and comprehensive for viruses and bacteria and age ranges to avoid bias. Expand
Schimke immuno-osseous dysplasia: a newly recognized multisystem disease.
A disorder characterized by skeletal dysplasia, rapidly progressive nephropathy, episodes of lymphopenia, and pigmentary skin changes is described, probably of genetic origin and inherited as an autosomal recessive trait. Expand
Early-life determinants of asthma from birth to age 20 years: a German birth cohort study.
Parental asthma and nasal allergy increase asthma incidence in offspring up to adulthood, and avoiding tobacco smoke exposure during pregnancy, receiving vaccinations in early childhood, and starting day care between 1.5 and 3 years of age might prevent or delay the development of asthma. Expand
Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine.
The data show that the vaccine induces T-cell responses specific for the vaccine components, detoxified pertussis toxin, filamentous hemagglutinin, and pertactin, that increase progressively over the course of the vaccination schedule, and cell-mediated immune responses are stable over the postprimary to prebooster period. Expand
Combined vaccination of Haemophilus influenzae type b conjugate and diphtheria-tetanus-pertussis containing acellular pertussis
The introduction of DTPa-Hib combinations are encouraged to facilitate the inclusion of Hib into the already crowded childhood immunisation schedule. Expand
Age-Dependent Association of Human Mannose-Binding Lectin Mutations With Susceptibility to Invasive Meningococcal Disease in Childhood
The data suggest that MBL exon 1 structural variants are significantly associated with susceptibility to childhood meningococcal disease in an age-dependent manner. Expand
Predictability of early atopy by cord blood‐IgE and parental history
Whether parental history and cord blood‐IgE were more accurate predictors for the appropriate atopic phenotypes in the infants rather than for any atopy is evaluated. Expand