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IL17A protein, human

Known as: Interleukin-17, Cytotoxic T-Lymphocyte-Associated Antigen 8, IL-17A, human 
Interleukin-17A (155 aa, ~18 kDa) is encoded by the human IL17A gene. This protein is involved in the positive regulation of cytokine production.
National Institutes of Health

Related topics

Related topics

16 relations
Cell Proliferation Regulatory ProcessCytokine GeneCytokine Receptor BindingCytokine Signaling

Broader (2)

Interleukin-17Interleukin-17A

Papers overview

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Highly Cited
2011
Highly Cited
2011
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
Lymphoid cells that express the nuclear hormone receptor RORγt are involved in containment of the large intestinal microbiota and… 
Highly Cited
2010
Highly Cited
2010
Blockade of Interleukin-17A Results in Reduced Atherosclerosis in Apolipoprotein E–Deficient Mice
Background— T cells play an important role during the immune response that accompanies atherosclerosis. To date, the role for… 
Highly Cited
2010
Highly Cited
2010
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
IL-22 has both proinflammatory and tissue-protective properties depending on the context in which it is expressed. However, the… 
Highly Cited
2010
Highly Cited
2010
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells
Mechanisms linking innate immunity and autoimmune responses are poorly understood. Myeloid-related protein-8 (Mrp8) and Mrp14 are… 
Highly Cited
2009
Highly Cited
2009
CCR6 and NK1.1 distinguish between IL‐17A and IFN‐γ‐producing γδ effector T cells
γδ T cells are a potent source of innate IL‐17A and IFN‐γ, and they acquire the capacity to produce these cytokines within the… 
Highly Cited
2008
Highly Cited
2008
Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice.
Highly Cited
2007
Highly Cited
2007
Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.
Highly Cited
2003
Highly Cited
2003
Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to Klebsiella pneumoniae Infection1
Local production of IL-17 is a significant factor in effective host defense against Gram-negative bacteria. However, the proximal… 
Highly Cited
2000
Highly Cited
2000
Increased interleukin-17 production in patients with systemic sclerosis.
OBJECTIVE To determine the role of a novel T cell-derived cytokine, interleukin-17 (IL-17), which activates fibroblasts and… 
Highly Cited
1997
Highly Cited
1997
Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage.
OBJECTIVE To examine the effect of human interleukin-17 (IL-17) on nitric oxide (NO) production in human osteoarthritis (OA… 
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