Increased interleukin-17 production in patients with systemic sclerosis.

@article{Kurasawa2000IncreasedIP,
  title={Increased interleukin-17 production in patients with systemic sclerosis.},
  author={Kazuhiro Kurasawa and Keiichi Hirose and Hajime Sano and Hirahito Endo and Hiroshi Shinkai and Y Nawata and Kazuhiro Takabayashi and Itsuo Iwamoto},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 11},
  pages={
          2455-63
        }
}
OBJECTIVE To determine the role of a novel T cell-derived cytokine, interleukin-17 (IL-17), which activates fibroblasts and endothelial cells, in the pathogenesis of systemic sclerosis (SSc). METHODS We examined IL-17 production by lymphocytes from the peripheral blood (PBL) and from fibrotic lesions of the skin and lungs of SSc patients by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay. We also studied the effect of IL-17 on the proliferation of… CONTINUE READING

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