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IFN-Stimulated Gene Factor 3 Complex

Known as: ISGF3 Factor, Interferon Stimulated Gene Factor 3, Transcription Factor ISGF3 
A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL… 
National Institutes of Health

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IRF9 geneIn BloodProcess of secretionagonists

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gamma interferon activation factor

Papers overview

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Review
2006
Review
2006
Identification of GAS‐dependent interferon‐sensitive target genes whose transcription is STAT2‐dependent but ISGF3‐independent
Signal transducer and activator of transcription 2 (STAT2) is best known as a critical transactivator component of the interferon… 
2001
2001
Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells.
Geranylgeranylacetone (GGA), an isoprenoid compound, is used clinically as an anti-ulcer drug. Since some isoprenoids including… 
1999
1999
Transcriptional induction of the p69 isoform of 2',5'-oligoadenylate synthetase by interferon-beta and interferon-gamma involves three regulatory elements and interferon-stimulated gene factor 3.
The 2',5'-oligoadenylate synthetases are key enzymes that mediate antiviral actions of interferon (IFN). The mRNAs for the… 
1999
1999
Induction of β-R1/I-TAC by Interferon-β Requires Catalytically Active TYK2*
The β-R1/I-TAC (interferon-inducible T-cell α-chemoattractant) gene encodes an α-chemokine that is a potent chemoattractant for… 
1999
1999
Organization of the genes encoding the human proteasome activators PA28α and β
Abstract Two proteasome activators PA28α and β, which have been implicated in antigen processing for loading class I MHC… 
1998
1998
Simultaneous but not sequential treatment with sodium butyrate improves the antiproliferative effect of alpha- or beta-interferon on a breast cancer cell line.
Clinical evidence indicates that alpha- and beta-interferon (alpha-IFN, beta-IFN) are only partially effective in human breast… 
1997
1997
The interferon-inducible murine p48 (ISGF3g) gene is regulated by protooncogene c-myc (transcriptionycell growthycytotoxic drugsyresistance)
p48 protein is an integral component of the multimeric interferon (IFN)-regulated transcription factor, ISGF3. We have shown… 
1996
1996
Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection.
The mechanism(s) by which interferon (IFN)-alpha confers resistance to viruses is currently being characterized. Previous studies… 
1996
1996
Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene.
Interferon stimulated gene factor 3 (ISGF3) is a trimeric transcription factor activated on treatment of cells with interferon… 
1992
1992
Induced expression of the endogenous beta interferon gene in adenovirus type 5-transformed rat fibroblasts
Tumorigenesis is a multistep process involving both genetic and epigenetic changes resulting in altered cellular gene expression… 
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