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IFN-Stimulated Gene Factor 3 Complex

Known as: ISGF3 Factor, Interferon Stimulated Gene Factor 3, Transcription Factor ISGF3 
A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL… Expand
National Institutes of Health

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IRF9 geneIn BloodProcess of secretionagonists
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gamma interferon activation factor

Papers overview

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Highly Cited
1999
Highly Cited
1999
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons.
Activation of cytosolic phospholipase A(2 )(cPLA(2)) is a prerequisite for the formation of the transcription factor complex… Expand
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Review
1999
Review
1999
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.
  • Markus H. Heim
  • Journal of receptor and signal transduction…
  • 1999
    • Corpus ID: 30161644
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction… Expand
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Highly Cited
1999
Highly Cited
1999
The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha.
Greater than 95% of all cervical carcinomas have been found to be associated with "high-risk" human papillomavirus (mainly types… Expand
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Highly Cited
1998
Highly Cited
1998
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7.
Interferon (IFN) genes are among the earliest transcriptional responses to virus infection of mammalian cells. Although the… Expand
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Highly Cited
1996
Highly Cited
1996
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2… Expand
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Highly Cited
1996
Highly Cited
1996
Autocrine amplification of type I interferon gene expression mediated by interferon stimulated gene factor 3 (ISGF3).
Interferon regulatory factor (IRF)-1 and IRF-2 have been implicated for the virus-induced expression of the interferon-alpha and… Expand
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Highly Cited
1995
Highly Cited
1995
Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.
Genes containing the interferon-stimulated response element (ISRE) enhancer have been characterized as transcriptionally… Expand
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Highly Cited
1995
Highly Cited
1995
Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3.
Many genes induced by type I interferons (IFNs) are also induced by double-stranded (ds)RAN. In this study, we investigated the… Expand
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1995
1995
Transcriptional induction of pim-1 protein kinase gene expression by interferon gamma and posttranscriptional effects on costimulation with steel factor.
Steel factor (SLF) synergizes with interferon gamma (IFN gamma) to stimulate proliferation of the human factor-dependent cell… Expand
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1993
1993
Double-stranded RNA activates novel factors that bind to the interferon-stimulated response element.
Infection of cells with adenovirus or transfection of cells with double-stranded RNA (dsRNA) activates transcription of the alpha… Expand
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