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Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia
It is found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adult micro glia and that microglian were absent in the CNS of TGF -β1–deficient mice.
Control of microglial neurotoxicity by the fractalkine receptor
Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX2CR1 antagonists could increase neuronal vulnerability.
Axonal transection in the lesions of multiple sclerosis.
- B. Trapp, J. Peterson, R. Ransohoff, R. Rudick, S. Mörk, L. Bö
- Medicine, BiologyThe New England journal of medicine
- 29 January 1998
Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Microglial physiology: unique stimuli, specialized responses.
A wealth of data now demonstrate that the microglia have very diverse effector functions, in line with macrophage populations in other organs, and the term activatedmicroglia needs to be qualified to reflect the distinct and very different states of activation-associated effector function in different disease states.
Neuroinflammation in Alzheimer's disease
The many roles of chemokines and chemokine receptors in inflammation.
The properties of chemokines and their receptors are discussed and the roles of these chemoattractants in selected clinical disorders are highlighted.
Interferons at age 50: past, current and future impact on biomedicine
The goal is to offer a molecular and clinical perspective that will enable IFNs or their TLR agonist inducers to reach their full clinical potential.
Three or more routes for leukocyte migration into the central nervous system
This review discusses three distinct routes for leukocyte entry into the central nervous system and considers how different populations of leukocytes use trafficking signals to gain entry.
Development, maintenance and disruption of the blood-brain barrier
This Review highlights recently gained mechanistic insights into the development and maintenance of the blood-brain barrier (BBB), and discusses how BBB disruption can cause or contribute to neurological disease.