Skip to search formSkip to main contentSkip to account menu

ICOSLG gene

Known as: GL50, B7 HOMOLOG 2, B7-H2 
This gene is involved in the regulation of T- and B-cell proliferation.
National Institutes of Health

Related topics

Related topics

8 relations
ICOSLG protein, humanImmune System ProcessesInducible T-Cell Co-Stimulator LigandStimulation of Cell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma
Myeloid dendritic cells (mDCs) and costimulatory molecules such as ICOSL/B7H2 play a pivotal role in murine experimental asthma… 
2014
2014
Commensal microbes drive intestinal inflammation by IL-17–producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2
Significance T-cell activation requires cognate antigen encounter plus additional stimulation through B7 costimulatory molecules… 
Highly Cited
2008
Highly Cited
2008
Down-Regulation of ICOS Ligand by Interaction with ICOS Functions as a Regulatory Mechanism for Immune Responses1
Although it is well-known that the ICOS-ICOS ligand (ICOSL) costimulatory pathway is important for many immune responses, recent… 
2006
2006
Structural Basis of Inducible Costimulator Ligand Costimulatory Function: Determination of the Cell Surface Oligomeric State and Functional Mapping of the Receptor Binding Site of the Protein1
Inducible costimulator (ICOS) ligand (ICOSL), a B7-related transmembrane glycoprotein with extracellular IgV and IgC domains… 
2006
2006
Effects of adenovirus-mediated gene transfer of ICOSIg and CTLA4Ig fusion protein on experimental autoimmune myocarditis
Objective: To explore the therapeutic alliance effects of adenovirus vector-mediated gene transfer of ICOSIg and CTLA4Ig fusion… 
2005
2005
Inhibition of Chronic Rejection and Development of Tolerogenic T Cells after ICOS-ICOSL and CD40-CD40L Co-stimulation Blockade
Background. Blockade of the CD40-CD40L pathway results in long-term allograft survival but does not prevent chronic rejection… 
2003
2003
Comparable in vivo efficacy of CD28/B7, ICOS/GL50, and ICOS/GL50B costimulatory pathways in murine tumor models: IFNgamma-dependent enhancement of CTL priming, effector functions, and tumor specific…
2003
2003
Interaction Between ICOS‐B7RP1 and B7‐CD28 Costimulatory Pathways in Alloimmune Responses In Vivo
The B7‐CD28 pathway is one of the foremost costimulatory pathways involved in T‐cell activation. Recently, a number of additional… 
2001
2001
Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells.
The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and… 
Highly Cited
2000
Highly Cited
2000
Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor
By the genetic selection of mouse cDNAs encoding secreted proteins, a B7-like cDNA clone termed mouse GL50 (mGL50) was isolated… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)