ICI 164384

So far, no combination of endocrine treatments has been routinely used in the therapy of breast Cancer. It was, therefore, our… Expand

Estrogens play an important role in the development and regulation of the male reproductive system. We have earlier shown that a… Expand

Abstract Prostaglandins (PGs) interact with specific receptors on plasma membranes to regulate myometrial activity in many… Expand

The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain… Expand

The rat estrogen receptor (ER) exists as two subtypes, ERα and ERβ, which differ in the C-terminal ligand binding domain and in… Expand

A novel estrogen receptor (hereinafter referred to as ER beta) was cloned using degenerate PCR primers. A comparison of the amino… Expand

SummaryThe mechanism of action of the pure antiestrogens ICI 164384 and ICI 182780 has been investigated. Both antagonists are… Expand

Non-steroidal antioestrogens, such as tamoxifen, inhibit the growth of human breast cancer cells. The experiments described here… Expand

Tamoxifen and other structurally related nonsteroidal antiestrogens possess properties in addition to their estrogen antagonist… Expand

The oestrogenic and antioestrogenic properties of some novel 7 alpha-alkyl amide derivatives of 17 beta-oestradiol have been… Expand