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Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
The rise in COX and NOS activities in the skin during the acute phase reinforces the proinflammatory role for prostanoids and suggests one also for nitric oxide and there may be differential regulation of these enzymes, perhaps due to the changing pattern of cytokines during the inflammatory response. Expand
Aberrant inflammation and resistance to glucocorticoids in Annexin 1−/− Mouse
It is reported that mice lacking the Anx‐1 gene exhibit a complex phenotype that includes an altered expression of other annexins as well as of COX‐2 and cPLA2 in response to carrageenin‐ or zymosan‐induced inflammation. Expand
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor‐dependent, transcription‐independent mechanism
The results point to an unsuspected rapid effect of glucocorticoids, mediated by occupation of GR but not by changes in gene transcription, which is brought about by competition between LC1 and Grb2 leading to a failure of recruitment off signalling factors to EGF‐R. Expand
A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation
It is shown that type VI iPLA2 drives the onset of acute pleurisy through the synthesis of PGE2, LTB4, PAF, and IL‐1β, and during resolution there is a switch to a sequential induction of first sPLA2 that mediates the release of PAF and lipoxin A4. Expand
Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line.
  • J. Croxtall, R. Flower
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 April 1992
The generation of prostaglandin E2 by A549 cells seems to be an important regulator of cell proliferation in vitro and the dexamethasone-induced suppression of proliferation in this model is attributable to eicosanoid inhibition caused by lipocortin 1. Expand
Different glucocorticoids vary in their genomic and non‐genomic mechanism of action in A549 cells
There is clear evidence of two entirely separate mechanisms of glucocorticoid action, one of which correlates with NF‐κB mediated genomic actions whilst the other, depends upon rapid effects on a cell signalling system which does not require dissociation of GR. Expand
Vildagliptin: a review of its use in the management of type 2 diabetes mellitus.
Oral vildagliptin in combination with metformin, a sulfonylurea or a thiazolidinedione improved glycaemic control in adults with type 2 diabetes and appeared to slow the progression of beta-cell degeneration in trials of 24-52 weeks' duration. Expand
Etravirine: a review of its use in the management of treatment-experienced patients with HIV-1 infection.
In highly treatment-experienced patients with HIV-1 infection and evidence of viral replication, the addition of etravirine to an optimized background therapy (OBT) regimen provides an effective and well tolerated treatment that leads to improvements in both virological and immunological outcomes. Expand
Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration
It is reported that LCI is mobilized and externalized following PMN adhesion to endothelial monolayers in vitro or to venular endothelium in vivo and that the end point of this process is a negative regulation of PMN transendothelial passage. Expand
Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation.
It is shown that EGF treatment of A549 cells stimulates phosphorylation of cytosolic phospholipase A2 (cPLA2) through a mechanism that is similarly inhibited by pertussis toxin, which strongly suggests that lipocortin 1 mediates the effect of dexamethasone by inhibiting activation of cPLA2. Expand