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IA 4

Known as: 8-chloro-2-(2-(diethylamino)ethyl)-2H-(1)benzothiopyrano(4,3,2-cd)indazole-5-methanol, IA-4 
National Institutes of Health

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Broader (1)

Hycanthone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules.
Review
1987
Review
1987
The I-J puzzle.
In 1976, several laboratories independently demonstrated that antibodies produced in major histocompatibility complex (MHC) I… 
1983
1983
Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoni.
1981
1981
Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro.
1979
1979
Structure of the high mannose oligosaccharides of a human IgM myeloma protein. II. The minor oligosaccharides of high mannose glycopeptide.
1977
1977
Mutagenic activities in vitro and in vivo of five antischistosomal compounds.
Five antischistosomal compounds--hycanthone, two of its chloroindazole analogs (IA-4 and IA-4 N-oxide), oxamniquine, and… 
Highly Cited
1976
Highly Cited
1976
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes
In an accompanying publication we show that a subpopulation of T lymphocytes, which includes allotype suppressor T cells… 
Highly Cited
1976
Highly Cited
1976
Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes
Data presented here show that locidentify in the I-region of the H-2 gene complex are selectively expressed in different… 
1976
1976
Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni.
In confirmation of an earlier study, it was found that in mice infected with Schistosoma mansoni hepatocellular carcinomas are… 
1973
1973
Mutagenic action of hycanthone and IA-4 on yeast.
Two antischistosomal compounds, hycanthone and IA-4, were tested for their mutagenicity in the yeast Saccharomyces cerevisiae… 
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