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Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. The condition… Expand Hyperalgesia and allodynia are frequent symptoms of disease and may be useful adaptations to protect vulnerable tissues. Both may… Expand Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of… Expand Peripheral inflammation induces p38 MAPK activation in the soma of C fiber nociceptors in the dorsal root ganglion (DRG) after 24… Expand The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed predominantly by sensory neurons. VR1… Expand Although physiological stimuli in the healthy gastrointestinal tract are generally not associated with conscious perception… Expand Hyperalgesia after cutaneous injury can be divided into two phenomena: Primary hyperalgesia occurs at the site of injury and is… Expand Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the… Expand 1. Psychophysical studies were made, in humans, of the sensory characteristics and underlying mechanisms of the hyperalgesia… Expand &NA; A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm… Expand