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Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine
Background It has been reported that &mgr;-opioid receptor activation leads to a sustained increase in glutamate synaptic effectiveness at the N-methyl-D-aspartate (NMDA) receptor level, a systemExpand
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JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
Peripheral nerve lesion leads to the production of interleukin 6 (IL‐6)‐related neuropoietic cytokines involved in nerve protection and regeneration. This family of cytokines mainly signal throughExpand
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Vulnerability to Depression: From Brain Neuroplasticity to Identification of Biomarkers
A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to characterize latent vulnerability traitsExpand
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Opioid-induced hyperalgesia: abnormal or normal pain?
INTRODUCTION It is well recognized that opioids are the analgesics of choice for the treatment of moderate to severe pain. However, a large number of clinical studies have reported that opioids canExpand
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Ketamine Improves the Management of Exaggerated Postoperative Pain Observed in Perioperative Fentanyl-treated Rats
Background:Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivityExpand
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Opioid and chemokine receptor crosstalk: a promising target for pain therapy?
Chemokines and opioids are important regulators of immune, inflammatory and neuronal responses in peripheral and central pain pathways. Recent studies have provided insights into the functionalExpand
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Spinal NK‐1 receptor‐expressing neurons and descending pathways support fentanyl‐induced pain hypersensitivity in a rat model of postoperative pain
The clinically important opioid fentanyl, administered acutely, enhances mechanical hypersensitivity in a model of surgical pain induced by plantar incision. Activity of neurokinin‐1 (NK‐1)Expand
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Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia
&NA; Chronic stressful events induce biochemical, physiological and psychological changes, resulting in stress‐related neuropsychiatric disorders, such as anxiety or depression. Using repeated socialExpand
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Non-Nociceptive Environmental Stress Induces Hyperalgesia, Not Analgesia, in Pain and Opioid-Experienced Rats
It is well admitted that stress induces analgesia (SIA) via endogenous opioid release. However, there is evidence that stressful events play a role in the pathogenesis of pain, but little is knownExpand
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The Role of Ketamine in Preventing Fentanyl-Induced Hyperalgesia and Subsequent Acute Morphine Tolerance
Perioperative opioids increase postoperative pain and morphine requirement, suggesting acute opioid tolerance. Furthermore, opioids elicit N-methyl-d-aspartate (NMDA)-dependent pain hypersensitivity.Expand
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