Hyper-IgM Immunodeficiency Syndrome, Type 1

Known as: HYPER-IgM SYNDROME, Immunodeficiencies, X-Linked Hyper-IgM, Syndrome, HIGM1 
An X-linked hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 LIGAND.
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
CD40 is a member of the tumor necrosis factor receptor superfamily, expressed on a wide range of cell types including B cells… (More)
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Highly Cited
2001
Highly Cited
2001
The gene that encodes nuclear factor κ (NF-κB) essential modulator (or NEMO, also known as IKKγ) is required for activation of… (More)
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Highly Cited
2000
Highly Cited
2000
The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal center B cells in mice, is a member of… (More)
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Highly Cited
1997
Highly Cited
1997
We report the clinical and immunologic features and outcome in 56 patients with X-linked hyper-IgM syndrome, a disorder caused by… (More)
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Highly Cited
1997
Highly Cited
1997
We report an association between X-linked immunodeficiency with hyper-IgM (XHIM) and carcinomas affecting the liver, pancreas… (More)
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Highly Cited
1995
Highly Cited
1995
We had previously shown that regularization principles lead to approximation schemes that are equivalent to networks with one… (More)
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Highly Cited
1993
Highly Cited
1993
The ligand for CD40 (CD40L) is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin… (More)
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Highly Cited
1993
Highly Cited
1993
XCHROMOSOME-LINKED immunodeficiency with hyper-IgM (HIGM1, MIM number 308230) is a rare disorder characterized by recurrent… (More)
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Highly Cited
1993
Highly Cited
1993
The prominent role of the CD40 receptor in B cell responses led us to investigate the role of the gp39-CD40 interaction in a… (More)
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Review
1992
Review
1992
Immunodeficiency with hyper-IgM (HIM) is a rare disorder characterized by recurrent infections associated with low IgG and IgA… (More)
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