• Publications
  • Influence
B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals
Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-livedExpand
  • 897
  • 63
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of pre-B cells in the bone marrow to develop into circulating mature B cells. A novel gene has been isolated whichExpand
  • 1,010
  • 26
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
Complementary DNA encoding the IgG1 induction factor, the first lymphokine directed to B lymphocytes, from a murine T-cell line has been cloned using a new strategy. The putative primary amino-acidExpand
  • 412
  • 7
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes.
Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114Expand
  • 611
  • 7
Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells
Genes were isolated using the suppression subtractive hybridization method by stimulation of pro/pre B cells with anti-CD40 and interleukin (IL)-4 to mature Sμ-Sε–switched cells. One of the stronglyExpand
  • 158
  • 7
  • PDF
Molecular and cellular aspects of X-linked agammaglobulinemia.
Publisher Summary The chapter discusses the current knowledge in the field of X-Linked Agammaglobulinemia (XLA) in the context of the recent developments. XLA, by being the first human disease causedExpand
  • 139
  • 3
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells1,2. These soluble factors are functionally divided into twoExpand
  • 383
  • 2
Identification of Btk mutations in 20 unrelated patients with X-linked agammaglobulinaemia (XLA).
X-linked agammaglobulinaemia (XLA) is an inherited immunodeficiency resulting from mutations in the gene for a cytoplasmic protein tyrosine kinase (Btk). We have utilised reverse-transcription-basedExpand
  • 57
  • 1
The human Iα1 region contains a TGF–β1 responsive enhancer and a putative recombination hotspot
: It appears that the switch recombination machinery of a B lymphocyte targets preferentially unrearranged heavy chain genes that have been rendered transcriptionally active. TranscriptionalExpand
  • 21
  • 1
Regulation of Germline Promoters by the Two Human Ig Heavy Chain 3′ α Enhancers1
The human IgH 3′ enhancers, located downstream of each of the two Cα genes, modulate germline (GL) transcription of the IgH genes by influencing the activity of promoter-enhancer complexes upstreamExpand
  • 31
  • 1