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  • Influence
Cloning of an Inr‐ and E‐box‐binding protein, TFII‐I, that interacts physically and functionally with USF1
The transcription factor TFII‐I has been shown to bind independently to two distinct promoter elements, a pyrimidine‐rich initiator (Inr) and a recognition site (E‐box) for upstream stimulatoryExpand
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Direct role for Myc in transcription initiation mediated by interactions with TFII-I
THE nuclear proto-oncoprotein Myc has been implicated in the control of cell proliferation and differentiation1–3. Myc participates in transcription4,5 and belongs to the basic–helix–loop–helixExpand
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Activation of class II gene transcription by regulatory factors is potentiated by a novel activity
A novel activity (USA) stimulated activator-dependent transcription in a reconstituted system in conjunction with natural TFIID, resulting in 10- to 50-fold levels of induction by regulatory factors.Expand
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Biochemistry and biology of the inducible multifunctional transcription factor TFII-I.
  • A. Roy
  • Biology, Medicine
  • Gene
  • 22 August 2001
An animal cell has the capability to respond to a variety of external signals through cell surface receptors. The response is usually manifested in terms of altered gene expression in the nucleus.Expand
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Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF
TRANSCRIPTION initiation by mammalian RNA polymerase II is effected by multiple common factors1,2 interacting through minimal promoter elements and regulated by gene-specific factors3 interactingExpand
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Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
The thyroid hormone receptor (TR) belongs to the steroid/nuclear receptor superfamily of ligand-inducible transcription factors. Numerous studies using transient transfection assays have demonstratedExpand
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Human transcription factor USF stimulates transcription through the initiator elements of the HIV‐1 and the Ad‐ML promoters.
Earlier in vitro studies identified USF as a cellular factor which activates the adenovirus major late (Ad‐ML) promoter by binding to an E‐box motif located at position −60 with respect to the capExpand
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A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.
The human homeodomain protein Phox1 interacts functionally with serum response factor (SRF) to impart serum responsive transcriptional activity to SRF-binding sites in a HeLa cell cotransfectionExpand
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Regulation of primary response genes.
Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression.Expand
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TFII-I Enhances Activation of the c-fosPromoter through Interactions with Upstream Elements
ABSTRACT The transcription factor TFII-I was initially isolated as a factor that can bind to initiator elements in core promoters. Recent evidence suggests that TFII-I may also have a role in signalExpand
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