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Hydroxymethyltransferases

Known as: Formyltransferases, formininotransferase, Transhydroxymethylases 
 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
The functional spectrum of a secretion system is defined by its substrates. Here we analyzed the secretomes of Pseudomonas… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To evaluate the contribution of metabolites (methotrexate [MTX] and folate polyglutamate [PG] levels) and… Expand
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Review
2004
Review
2004
SUMMARY The availability of a large number of complete genome sequences raises the question of how many genes are essential for… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Methotrexate (MTX) enters cells through the reduced folate carrier (RFC-1) and exerts part of its effects through… Expand
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Highly Cited
2002
Highly Cited
2002
Folate-dependent one-carbon metabolism is required for the synthesis of purines and thymidylate and for the remethylation of… Expand
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Highly Cited
1999
Highly Cited
1999
The folate receptor (FR) type alpha is known to be frequently overexpressed in ovarian cancer and is the target for a number of… Expand
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Highly Cited
1999
Highly Cited
1999
We present a methodology, termed incremental truncation for the creation of hybrid enzymes (ITCHY), that creates combinatorial… Expand
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Highly Cited
1997
Highly Cited
1997
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo… Expand
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Highly Cited
1991
Highly Cited
1991
Although commonly used to control a variety of inflammatory diseases, the mechanism of action of a low dose of methotrexate… Expand
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Highly Cited
1985
Highly Cited
1985
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic… Expand
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