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Hybridomas

Known as: Hybridoma, cell hybridoma 
A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line… 
National Institutes of Health

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Broader (2)

Cell hybridizationClone Cells
HeLa CellsInterleukin-6KB CellsMicrobiological

Papers overview

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1989
1989
Oxygen Transport to Tissue XI
The Ottawa '88 meeting of the International Society for Oxygen Transport to Tissue attracted a record number of participants and… 
1987
1987
Human monocyte-mediated cytotoxicity: the use of Ig-bearing hybridomas as target cells to detect trigger molecules on the monocyte cell surface.
We recently reported the preparation and characterization of a monoclonal antibody, 32.2, specific for the high-affinity Fc… 
1985
1985
Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas.
The heavy chain isotype switch is mediated by a DNA rearrangement between a donor switch region (usually mu) and a recipient… 
1985
1985
Fine specificity of antigen recognition by T cell hybridoma clones specific for poly-18: a synthetic polypeptide antigen of defined sequence and conformation.
Antigen-specific T cell blasts to poly-18, a polypeptide antigen of defined sequence and conformation, were generated from lymph… 
Highly Cited
1984
Highly Cited
1984
Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas.
We have employed bifunctional T cell hybridomas, which can be stimulated to secrete lymphokine(s) and lyse specific target cells… 
1984
1984
Macrophage-hybridomas: generation, structure, and function.
We report the generation of macrophage-hybridomas, obtained by somatic cell fusion between macrophage-enriched C3H.eB spleen cell… 
1983
1983
Inhibition of IgE production in B hybridomas by IgE class-specific suppressor factor from T hybridomas.
The function of IgE class-specific suppressor factor (IgE-TsF) from T hybridomas was studied by employing IgE-producing B… 
1981
1981
Hybridoma-derived antibody with immunodiagnostic potential for schistosomiasis japonica.
A murine hybridoma-derived antibody (IPH.134) has been produced which has apparent high binding specificity for an extract of… 
Highly Cited
1980
Highly Cited
1980
Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. I. A hybridoma secreting antibody against a marker specific for human B lymphocytes.
A hybridoma has been isolated from the products of fusion of a myeloma cell line with spleen cells from mice immunized with a… 
Highly Cited
1980
Highly Cited
1980
Differentiation of human B cells expressing the IgA subclasses as demonstrated by monoclonal hybridoma antibodies.
Monoclonal hybridoma antibodies to the human IgA subclasses were produced by immunizing mice with purified myeloma proteins…