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Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice.
Antigen-induced arthritis was established in the mouse by immunizaiton with methylated bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertusis vaccine. The knee joint was injectedExpand
Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach?
The present strong emphasis on gross organ pathology (liver, kidneys, bladder) in schistosomiasis needs to be replaced with a more balanced view of the disease that also takes into account systemicExpand
Immunological activity of thymus and thoracic-duct lymphocytes.
In heavily irradiated mice, an inoculum containing a mixture of marrow and thymus cells allowed the production of more hemolysins against sheep erythrocytes than could be accounted for by summating the activities of each cell population alone. Expand
It is suggested that there are cell types, in thymus or thoracic duct lymph, with capacities to react specifically with antigen and to induce the differentiation, to antibody-forming cells, of hemolysin-forming cell precursors derived from a separate cell line present in the neonatally thymectomized hosts. Expand
Antigen-induced selective recruitment of circulating lymphocytes.
Thoracic duct lymphocytes obtained from mice 1–2 days after the injection of sheep erythrocytes and injected into thymectomized, irradiated, marrow-protected syngeneic hosts were deficient in adoptively transferring immune reactivity but normal with respect to horse ery Throatcytes. Expand
Antigen‐induced arthritis in mice
Antigen-induced arthritis was established in the mouse by immunization with methylated bovine serum albumin (mBSA) in complete Freund's adjuvant with B pertussis vaccine. The knee joint was injectedExpand
Mr 26,000 antigen of Schistosoma japonicum recognized by resistant WEHI 129/J mice is a parasite glutathione S-transferase.
Although vaccination studies in mice with a beta-galactosidase-Sj26 fusion protein from Escherichia coli are encouraging, more immunogenic preparations of the antigen are likely to be required to establish the utility of Sj26 as a model vaccine. Expand
Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep.
The results show that GST of adult F. hepatica is a novel Ag that can significantly protect sheep against liver fluke infection and suggest that the immune response to GST is directed to the juvenile worm reducing the number of worms that can establish in the liver of the vaccinated animals. Expand
Proteolytic cleavage of immunoglobulin by enzymes released by Fasciola hepatica.
Immature Fasciola hepatica release a papain or cathepsin B-like proteolytic enzyme which cleaves immunoglobulins of mouse, rat, rabbit and sheep in vitro, which has been identified as a thiol protease. Expand
An immunogenic Mr 23,000 integral membrane protein of Schistosoma mansoni worms that closely resembles a human tumor-associated antigen.
A Mr 23,000 Ag of the human trematode parasite, Schistosoma mansoni, has been identified by immunoscreening an adult worm cDNA library with antibody affinity purified on the Mr 23,000 to 25,000Expand