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Your love and endless support keep me afloat. iv ACKNOWLEDGEMENTS I would like to acknowledge those whose guidance and support… Expand Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors… Expand Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H/HeJ and C57BL/10ScCr mice… Expand The author would like to thank Maureen Murphy, Stuart Lutzker, and Deborah Freedman for critical input and advice. The author… Expand A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed restrictively in fetal development. To… Expand THE endothelial cell-specific vascular endothelial growth factor (VEGF)1–5 and its cellular receptors Flt-1 (refs 6,7) and Flk-1… Expand Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4… Expand THE receptor tyrosine kinase Flk-1 (ref. 1) is believed to play a pivotal role in endothelial development. Expression of the Flk… Expand The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic… Expand Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the… Expand