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Adaptive protein evolution at the Adh locus in Drosophila
PROTEINS often differ in amino-acid sequence across species. This difference has evolved by the accumulation of neutral mutations by random drift, the fixation of adaptive mutations by selection, orExpand
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The population genetics of the origin and divergence of the Drosophila simulans complex species.
The origins and divergence of Drosophila simulans and close relatives D. mauritiana and D. sechellia were examined using the patterns of DNA sequence variation found within and between species at 14Expand
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Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of theExpand
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Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis
The co-evolutionary ‘arms race’ is a widely accepted model for the evolution of host–pathogen interactions. This model predicts that variation for disease resistance will be transient, and that hostExpand
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Evolutionary Dynamics of Plant R-Genes
Plant R-genes involved in gene-for-gene interactions with pathogens are expected to undergo coevolutionary arms races in which plant specificity and pathogen virulence continually adapt in responseExpand
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Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila.
Evolutionary analysis of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are subject to weak selection at the translation level. Here we show that theExpand
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Analysis of conserved noncoding DNA in Drosophila reveals similar constraints in intergenic and intronic sequences.
Comparative genomic approaches to gene and cis-regulatory prediction are based on the principle that differential DNA sequence conservation reflects variation in functional constraint. Using thisExpand
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Evidence for stabilizing selection in a eukaryotic enhancer element
Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers, which are bound by specific sets of transcription factors. The combinatorial interaction of these boundExpand
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Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes
Mutation hotspots are commonly observed in genomic sequences and certain human disease loci, but general mechanisms for their formation remain elusive. Here we investigate the distribution ofExpand
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The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces.
Intron length is negatively correlated with recombination in both Drosophila melanogaster and humans. This correlation is not likely to be the result of mutational processes alone: evolutionaryExpand
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