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High Affinity Immunoglobulin Gamma Fc Receptor I, human

Known as: Fc Gamma Receptor, IgG Fc Receptor I, CD64 Antigen 
High affinity immunoglobulin gamma Fc receptor I (374 aa, ~43 kDa) is encoded by the human FCGR1A gene. This protein is involved in the immune… 
National Institutes of Health

Related topics

Related topics

12 relations
Antigen PresentationAntigen ProcessingFCGR1A geneImmunoglobulin C2-set Domain

Broader (1)

CD64 Antigen

Papers overview

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Highly Cited
2012
Highly Cited
2012
CD64 Expression Distinguishes Monocyte-Derived and Conventional Dendritic Cells and Reveals Their Distinct Role during Intramuscular Immunization
Although most vaccines are administered i.m., little is known about the dendritic cells (DCs) that are present within skeletal… 
Highly Cited
2009
Highly Cited
2009
Macrophages in Vaginal but Not Intestinal Mucosa Are Monocyte-Like and Permissive to Human Immunodeficiency Virus Type 1 Infection
ABSTRACT Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis, and yet… 
Highly Cited
2006
Highly Cited
2006
The high-affinity IgG receptor, FcgammaRI, plays a central role in antibody therapy of experimental melanoma.
We examined the role of FcgammaR in antibody therapy of metastatic melanoma in wild-type and different FcgammaR knock-out mice… 
Highly Cited
2004
Highly Cited
2004
Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage
Highly Cited
2003
Highly Cited
2003
Post-Traumatic Osteomyelitis: Analysis of Inflammatory Cells Recruited into the Site of Infection
Device-associated infections after implants or endoprostheses inflict local inflammation and ultimately osteolysis, a clinical… 
Highly Cited
1997
Highly Cited
1997
Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fc gamma RI (CD64) expressed on human blood dendritic cells.
The mechanisms responsible for efficient sequestration of Ag by cells of the dendritic cell (DC) lineage remain incompletely… 
Highly Cited
1996
Highly Cited
1996
Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice.
Besides their phagocytic effector functions, myeloid cells have an essential role as accessory cells in the induction of optimal… 
Highly Cited
1996
Highly Cited
1996
FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo.
Most Ig receptors exist as hetero-oligomeric complexes with separate ligand binding (alpha) and signal transducing (beta, gamma… 
Highly Cited
1994
Highly Cited
1994
The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI.
The high affinity Fc gamma receptor, Fc gamma RI, is unique among the three classes of macrophage Fc gamma receptors not only in… 
Highly Cited
1994
Highly Cited
1994
Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn
The high affinity immunoglobulin G (IgG) receptor Fc gamma RI (CD64) is expressed constitutively on monocytes and macrophages… 
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