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HTR3A gene

Known as: 5-HYDROXYTRYPTAMINE RECEPTOR 3, SEROTONIN 5-HT-3 RECEPTOR, HTR3A 
This gene plays a role in neurotransmitter modulation and in chaperone activity.
National Institutes of Health

Related topics

Related topics

6 relations
HTR3A protein, humanHTR3A wt AlleleLigand BindingReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Discriminating between 5-HT3A and 5-HT3AB receptors
The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit results in heteromeric 5‐HT3AB receptors… 
2007
2007
Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression
Background The serotonin [5-hydroxytryptamine (5-HT)]-gated ion channel 5-HT3 is involved in the mediation of postoperative and… 
2006
2006
An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization Mechanism*
A large cytoplasmic domain accounts for approximately one-third of the entire protein of one superfamily of ligand-gated membrane… 
2005
2005
Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome.
Serotonin has been implicated in a variety of neuropsychiatric disorders. Serotonergic dysfunction is thought to be involved in… 
Highly Cited
2004
Highly Cited
2004
Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists.
OBJECTIVES Acute cytostatic drug induced nausea and vomiting is provoked by a release of endogenous serotonin that mediates its… 
Highly Cited
2004
Highly Cited
2004
Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5‐HT3A) are co‐expressed in GABA neurons in the rat telencephalon
Among all described serotonin (5‐HT) receptors in mammals, the type three (5‐HT3) is the only ligand‐gated ion channel receptor… 
2004
2004
Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.
The 5-HT3A receptor, a ligand-gated ion channel, is involved in pain pathways, nausea and emesis, and irritable bowel syndrome… 
Highly Cited
2003
Highly Cited
2003
Arginine 222 in the Pre-transmembrane Domain 1 of 5-HT3A Receptors Links Agonist Binding to Channel Gating*
Ligand-gated ion channels are integral membrane proteins that mediate fast synaptic transmission. Molecular biological techniques… 
Highly Cited
2000
Highly Cited
2000
Modified 5-HT3A receptor function by co-expression of alternatively spliced human 5-HT3A receptor isoforms
Serotonin (5-HT) exerts fast excitatory responses by activation of 5-HT3 receptors, irrespective of whether they are… 
2000
2000
Exon-intron organization of the human 5-HT3A receptor gene
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