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Differential Compartmentalization and Distinct Functions of GABAB Receptor Variants
Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients
- P. Wellendorph, L. D. Johansen, H. Bräuner‐Osborne
- Biology, MedicineMolecular Pharmacology
- 1 September 2009
The ligand-receptor interactions of the promiscuous receptors of organic nutrients thus remain an interesting subject of emerging functional importance.
Real-time trafficking and signaling of the glucagon-like peptide-1 receptor
Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Cinacalcet is the first allosteric GPCR modulator to enter the market, which demonstrates that the therapeutic principle of allosterics modulation can also be extended to this important drug target class.
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
The results demonstrate that G-protein-coupled receptors can activate the inflammasome, and indicate that increased extracellular calcium has a role as a danger signal and amplifier of inflammation.
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an…
The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain*
- H. Bräuner‐Osborne, A. Jensen, P. Sheppard, P. O'Hara, P. Krogsgaard‐Larsen
- BiologyThe Journal of Biological Chemistry
- 25 June 1999
A chimeric receptor named Ca/1a is constructed consisting of the ATD of CaR and the seven transmembrane region and C terminus of mGlu1a, which demonstrates that Ser-170 and to some extent Ser-147 are involved in the Ca2+ activation of the CaR, and reveals a close resemblance of the activation mechanism between the CaGlu receptors.
Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.
Agonists and Inverse Agonists for the Herpesvirus 8-encoded Constitutively Active Seven-transmembrane Oncogene Product, ORF-74*
- M. Rosenkilde, T. Kledal, H. Bräuner‐Osborne, T. Schwartz
- Biology, ChemistryThe Journal of Biological Chemistry
- 8 January 1999
It is concluded that ORF-74, which is believed to be causally involved in the formation of highly vascularized tumors, has been optimized for agonist and inverse agonist modulation by the endogenous angiogenic GRO peptides and angiostatic IP-10 and stromal cell-derived factor-1α, respectively.