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HPSE gene

Known as: HPA, HPA1, HPSE1 
This gene plays a role in the disassembly of the extracellular matrix by invading cells.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the… Expand
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Review
2006
Review
2006
Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme… Expand
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Highly Cited
2006
Highly Cited
2006
Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate moieties and hence participates in… Expand
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Highly Cited
2004
Highly Cited
2004
We have generated homozygous transgenic mice (hpa-tg) overexpressing human heparanase (endo-beta-D-glucuronidase) in all tissues… Expand
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Review
2001
Review
2001
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of… Expand
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Highly Cited
2001
Highly Cited
2001
SPECIFIC AIMSOur objective was to study the involvement and mode of action of mammalian heparanase, endo-β-D-glucuronidase… Expand
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Highly Cited
1999
Highly Cited
1999
Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of… Expand
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Highly Cited
1999
Highly Cited
1999
The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably… Expand
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Highly Cited
1999
Highly Cited
1999
Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug candidates for cancer therapy. To… Expand
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Review
1992
Review
1992
Interaction of T and B lymphocytes, platelets, granulocytes, macrophages and mast cells with the subendothelial extracellular… Expand
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