HPSE gene

Known as: HPA, HPA1, HPSE1 
This gene plays a role in the disassembly of the extracellular matrix by invading cells.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2018
02040608019652018

Papers overview

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2012
2012
The Current Study aimed to investigate the possible role of Heparanase protein (HPSE-1, [Entrez Pubmed ref|NP_001092010.1… (More)
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Highly Cited
2010
Highly Cited
2010
Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase and shed syndecan-1 in the tumor… (More)
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Highly Cited
2007
Highly Cited
2007
When shed from the cell surface, the heparan sulfate proteoglycan syndecan-1 can facilitate the growth, angiogenesis, and… (More)
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Highly Cited
2006
Highly Cited
2006
Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate moieties and hence participates in… (More)
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Highly Cited
2004
Highly Cited
2004
Heparanase is a mammalian endoglycosidase that degrades heparan sulfate (HS) at specific intra-chain sites. Blood-borne… (More)
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Highly Cited
2003
Highly Cited
2003
Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with… (More)
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Highly Cited
2001
Highly Cited
2001
Extracellular matrix (ECM) and basement membranes (BMs) present a physical barrier that requires enzymatic degradation during… (More)
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Highly Cited
1999
Highly Cited
1999
Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of… (More)
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Highly Cited
1999
Highly Cited
1999
The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably… (More)
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Highly Cited
1999
Highly Cited
1999
Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug candidates for cancer therapy. To… (More)
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