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HPSE gene

Known as: HPA, HPA1, HPSE1 
This gene plays a role in the disassembly of the extracellular matrix by invading cells.
National Institutes of Health

Related topics

Related topics

7 relations
Angiogenic ProcessBlood coagulationCell-Matrix JunctionHydrolysis

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HPSE wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg-Marquardt algorithm.
Highly Cited
2004
Highly Cited
2004
Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis
Heparanase is considered to play an important role in tumor invasion and hematogenous metastasis. The aim of this study was to… 
Highly Cited
2002
Highly Cited
2002
Implantation and placental development in somatic cell clone recipient cows.
Successful somatic cloned animal production has been reported in various domesticated species, including cattle; however, it is… 
Highly Cited
2000
Highly Cited
2000
Heparanase expression in invasive trophoblasts and acute vascular damage.
Heparan sulfate proteoglycans play a pivotal role in tissue function, development, inflammation, and immunity. We have identified… 
Highly Cited
1998
Highly Cited
1998
Regulation of platelet heparanase during inflammation: Role of pH and proteinases
Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and… 
Highly Cited
1995
Highly Cited
1995
CXC Chemokines Connective Tissue Activating Peptide-III and Neutrophil Activating Peptide-2 are Heparin/Heparan Sulfate-degrading Enzymes (*)
Heparan sulfate proteoglycans at cell surfaces or in extracellular matrices bind diverse molecules, including growth factors and… 
Highly Cited
1995
Highly Cited
1995
Comparative analysis of the ability of leucocytes, endothelial cells and platelets to degrade the subendothelial basement membrane: Evidence for cytokine dependence and detection of a novel sulfatase
The subendothelial basement membrane (BM) is regarded as an important barrier to the entry of leucocytes into inflammatory sites… 
Highly Cited
1993
Highly Cited
1993
Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production
The role of growth factor networks in regulating the progression of human melanocytes towards tumorigenicity and ultimately the… 
Highly Cited
1993
Highly Cited
1993
A critical role for heat shock transcription factor in establishing a nucleosome‐free region over the TATA‐initiation site of the yeast HSP82 heat shock gene.
Heat shock genes are poised for rapid transcriptional activation in response to environmental stress. A universal structural… 
Highly Cited
1985
Highly Cited
1985
Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells
A highly metastatic variant (ESb) of a methylchol‐anthrene‐induced T lymphoma elaborates a heparan sulfate (HS) degrading… 
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