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HPSE wt Allele

Known as: HPA, HPSE1, HEP 
Human HPSE wild-type allele is located in the vicinity of 4q21.3 and is approximately 43 kb in length. This allele, which encodes heparanase protein… 
National Institutes of Health

Related topics

Related topics

8 relations
4q21.3Angiogenic ProcessBlood coagulationCell-Matrix Junction

Broader (1)

HPSE gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Heparanase promotes radiation resistance of cervical cancer by upregulating hypoxia inducible factor 1.
Heparanase (HPSE1) is elevated in various types of cancers including cervical cancer, and correlated with poor prognosis. Current… 
2010
2010
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1
Heat shock transcription factor-1 (HSF-1) is the primary stress responsive transcription factor that regulates expression of heat… 
2010
2010
Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.
Heparanase-1 (HPR1), an endoglycosidase that specifically degrades heparan sulfate (HS) proteoglycans, is overexpressed in a… 
2007
2007
In Vivo and in Vitro Degradation of Heparan Sulfate (HS) Proteoglycans by HPR1 in Pancreatic Adenocarcinomas
Heparan sulfate proteoglycans (HSPGs) function as a co-receptor for heparin-binding growth factors, such as fibroblast growth… 
2005
2005
Ductal carcinoma in situ of the breast and heparanase-1 expression: a molecular explanation for more aggressive subtypes.
Highly Cited
2002
Highly Cited
2002
Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter
Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate chains of proteoglycan, a component of… 
Highly Cited
1997
Highly Cited
1997
The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11.
We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination… 
1992
1992
Uncoupling gene activity from chromatin structure: promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome-free regions.
DNase I-hypersensitive sites represent "nucleosome-free" regions in chromatin where the underlying DNA sequence is highly… 
Review
1990
Review
1990
Promoter function and in situ protein/DNA interactions upstream of the yeast HSP90 heat shock genes
We have mapped in vivo protein/DNA interactions within the upstream regulatory regions of the two yeast HSP90 genes, and have… 
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