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High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines.
TLDR
Observations suggest that mutated BRAF gene may cooperate with RET/PTC to induce the oncogenesis of PTC, and a large number of BRAF-mutated PTCs also expressed RET, indicating that the RET proto-oncogene is rearranged in these BRA fusions. Expand
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations
TLDR
In the current study, genetic alterations in a panel of ATC were profiled to determine the origins of A TC. Expand
Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients.
TLDR
Functional analysis revealed that renal epithelial cells grown under high glucose conditions resulted in an increase of basement membrane permeability to albumin, and studies suggest that loss of heparan sulfate in the GBM with diabetic nephropathy is attributable to accelerated heparin sulfate degradation by increased HPR1 expression. Expand
Demonstration of Epstein-Barr virus in carcinomas of various sites.
TLDR
The results suggest that EBV is not restricted to lymphoepithelioma-like carcinomas but may play an oncogenic role in frequent epithelial cancers and possibly also in hyperplasias and certain dysplasia preceding carcinomas. Expand
Fine-needle aspiration of clinically suspicious palpable breast masses with histopathologic correlation.
TLDR
Compared with previous studies, fine-needle aspiration is an excellent diagnostic tool in assessing clinically palpable breast masses and the overall rate of false-positive and false-negative cases is comparable with published literature. Expand
Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases.
TLDR
Total thyroidectomy may be considered an appropriate operative treatment in patients with Hashimoto's thyroiditis and follicular adenoma requiring operation owing to the high incidence and frequent contralateral involvement of IPC, respectively. Expand
Correlation of Her‐2/neu Gene Amplification with Other Prognostic and Predictive Factors in Female Breast Carcinoma
TLDR
Correlation was found between Her‐2/neu amplification and tumor type, high histological grade, ER and PR negative tumors, and high proliferative MIB‐1 index, while size of the tumor and age of the patients were not statistically significant. Expand
Incidence of neoplasia in Hashimoto's thyroiditis: A fine‐needle aspiration study
TLDR
The cytologic changes in the hyperplastic follicular and metaplastic oncocytic epithelium are similar to those seen in follicular neoplasm, and thus, in the presence of HT, the diagnosis of follicularNeoplasm probably should not be rendered. Expand
Heparanase-1 expression is associated with the metastatic potential of breast cancer.
TLDR
HPR1 expression correlates with the lack of HS deposition and with the metastatic potential of breast cancers, and the frequency of HPR1 is significantly higher in breast tumors between 1 and 5 cm than in tumors < or =1 cm. Expand
Diagnosis of Blastomycosis in Surgical Pathology and Cytopathology: Correlation With Microbiologic Culture
TLDR
This study shows that blastomycosis encountered in surgical/cytopathology can be reliably diagnosed by morphologic examination allowing for prompt treatment, however, microbiologic cultures still play a major role in clinical management of patients suspected of infection because 10.25% were false negative on morphology in this study. Expand
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