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HMGB1 Protein

Known as: p30, Heparin-Binding Protein, High Mobility Group Protein B1, SBP-1 
High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
A key question in immunology concerns how sterile injury activates innate immunity to mediate damaging inflammation in the… Expand
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Review
2010
Review
2010
The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. Cell death through… Expand
Highly Cited
2010
Highly Cited
2010
This corrects the article DOI: 10.1038/nature00858 
Review
2008
Review
2008
While foreign pathogens and their products have long been known to activate the innate immune system, the recent recognition of a… Expand
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Highly Cited
2007
Highly Cited
2007
Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as… Expand
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Review
2007
Review
2007
Summary: Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but… Expand
Review
2005
Review
2005
High-mobility group box 1 protein (HMGB1), which previously was thought to function only as a nuclear factor that enhances… Expand
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Highly Cited
2003
Highly Cited
2003
High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation… Expand
Highly Cited
2002
Highly Cited
2002
High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an… Expand
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Highly Cited
2002
Highly Cited
2002
HMGB1, a non‐histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question… Expand