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A key question in immunology concerns how sterile injury activates innate immunity to mediate damaging inflammation in the… Expand The immune system has evolved to respond not only to pathogens, but also to signals released from dying cells. Cell death through… Expand
This corrects the article DOI: 10.1038/nature00858
While foreign pathogens and their products have long been known to activate the innate immune system, the recent recognition of a… Expand Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as… Expand Summary: Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but… Expand High-mobility group box 1 protein (HMGB1), which previously was thought to function only as a nuclear factor that enhances… Expand High Mobility Group 1 protein (HMGB1) is a chromatin component that, when leaked out by necrotic cells, triggers inflammation… Expand High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an… Expand HMGB1, a non‐histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question… Expand